2. Cell Cycle/DNA Damage JAK/STAT Signaling Apoptosis
  3. CDK Pim Apoptosis
  4. CDK6/PIM1-IN-1 hydrochloride

CDK6/PIM1-IN-1 (Compound 51) hydrochloride is an orally active and potent dual CDK6/PIM1 inhibitor with IC50 values of 39 and 88 nM, respectively. CDK6/PIM1-IN-1 hydrochloride inhibits CDK4 (IC50=3.6 nM). CDK6/PIM1-IN-1 hydrochloride significantly inhibits acute myeloid leukemia (AML) cell proliferation, arrest cell cycle at the G1 phase, and promote cell apoptosis. CDK6/PIM1-IN-1 exhibits potent anti-AML activity.

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CDK6/PIM1-IN-1 hydrochloride Chemical Structure

CDK6/PIM1-IN-1 hydrochloride Chemical Structure

CAS No. : 2677026-15-0

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Other Forms of CDK6/PIM1-IN-1 hydrochloride:

CDK6/PIM1-IN-1 hydrochloride Related Antibodies

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PIM1 PIM2 PIM3

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Description

CDK6/PIM1-IN-1 (Compound 51) hydrochloride is an orally active and potent dual CDK6/PIM1 inhibitor with IC50 values of 39 and 88 nM, respectively. CDK6/PIM1-IN-1 hydrochloride inhibits CDK4 (IC50=3.6 nM). CDK6/PIM1-IN-1 hydrochloride significantly inhibits acute myeloid leukemia (AML) cell proliferation, arrest cell cycle at the G1 phase, and promote cell apoptosis. CDK6/PIM1-IN-1 exhibits potent anti-AML activity[1].

IC50 & Target

CDK6

39 nM (IC50)

PIM1

88 nM (IC50)

CDK4

3.6 nM (IC50)

Molecular Weight

510.01

Formula

C25H29ClFN9
CAS No.
Appearance

Solid

Color

Yellow to orange

SMILES

FC1=CN=C(NC2=NC=C(N3CCNCC3)C=C2)N=C1C4=CC=C5N=CC(N(CC)CC)=NC5=C4.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Purity & Documentation
References
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CDK6/PIM1-IN-1 hydrochloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CDK6/PIM1-IN-12677026-15-0CDKPimApoptosisCyclin dependent kinasePim kinasesacute myeloid leukemiaAMLG1 phaseK562HL-60MOLM13 cellInhibitorinhibitorinhibit

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