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LL/2 syngeneic model

" in MedChemExpress (MCE) Product Catalog:

4072

Inhibitors & Agonists

9

Screening Libraries

25

Fluorescent Dye

166

Biochemical Assay Reagents

304

Peptides

2

MCE Kits

133

Inhibitory Antibodies

405

Natural
Products

2

Recombinant Proteins

101

Isotope-Labeled Compounds

1

Antibodies

28

Click Chemistry

82

Oligonucleotides

Cat. No. Product Name Target Research Areas Chemical Structure
  • HY-P1425
    (Z-LL)2 ketone

    		Ser/Thr Protease Neurological Disease
    (Z-LL)2 ketone is an inhibitor of ketone with an IC50 value of 50 nM. (Z-LL)2 ketone inhibits processing of thep-Prlsignal peptide .
    (Z-LL)2 ketone
  • HY-P1513A
    LL-37 scrambled peptide acetate

    		Bacterial Infection
    LL-37 scrambled peptide acetate is a scrambled version of cathelicidin anti-microbial peptide LL-37. LL-37 scrambled peptide acetate can be used as a negative control of LL-37 peptide studies.
    LL-37 scrambled peptide acetate
  • HY-P99464
    Bectumomab

    IMMU-LL 2

    		 CD22 Cancer
    Bectumomab (IMMU-LL 2) is an humanized IgG2a mAb against human CD22 (antigen). Bectumomab is also an anti-lymphoma antibody fragment. Bectumomab can be used for imaging in combination with technetium 99 (Tc99m LL2 Fab). Moreover, Bectumomab examines in the staging of recurrent or newly diagnosed non-Hodgkin's lymphoma (NHL) and to assess targeting before radioimmunoresearch (RIT) .
    Bectumomab
  • HY-P5729
    LL-25

    		Fungal Infection
    LL-25 is a fragment of LL-37 (HY-P1222) but devoid of the immunomodulatory properties of LL-37. LL-25 has antifungal and candidacidal activity .
    LL-25
  • HY-P4746
    LL-37 FKR

    		Bacterial Infection
    LL-37 FKR is the C-terminal fragment of LL-37. LL-37 FKR plays an important role in antibacterial performance [2].
    LL-37 FKR
  • HY-P4128
    LL-37 SKE

    		Bacterial Antibiotic Others
    LL-37 SKE is an active fragment of LL-37 .
    LL-37 SKE
  • HY-P4751
    LL-37 RKS

    		Bacterial Others
    LL-37 RKS is an active fragment of LL-37 .
    LL-37 RKS
  • HY-P4747
    LL-37 GKE

    		Antibiotic Bacterial Infection
    LL-37 GKE is an active domain of LL-37. LL-37 GKE has antibacterial activity and has potential applications in antibiotics [2].
    LL-37 GKE
  • HY-P1513
    LL-37 scrambled peptide

    		Bacterial Infection
    LL-37 scrambled peptide is a scrambled version of cathelicidin anti-microbial peptide LL-37. LL-37 scrambled peptide can be used as a negative control of LL-37 peptide studies.
    LL-37 scrambled peptide
  • HY-P10262
    LL-37-Cys

    		Drug Derivative Others
    LL-37-Cys is a LL-37 (HY-P1222) with a C-terminal reduced cystein residue [1][.
    LL-37-Cys
  • HY-P4744
    LL-37 amide
    1 Publications Verification

    		 Bacterial Infection Cancer
    LL-37 amide is a positively charged antimicrobial peptide. LL-37 amide has anticancer activity and can be used for cancer research [2].
    LL-37 amide
  • HY-18234C
    Leupeptin Ac-LL hydrochloride

    		Biochemical Assay Reagents Inflammation/Immunology Cancer
    Leupeptin Ac-LL (hydrochloride) is the hydrochloride form of Leupeptin Ac-LL (HY-18234B). Leupeptin Ac-LL (hydrochloride) has better inhibition than Leupeptin Ac-LL .
    Leupeptin Ac-LL hydrochloride
  • HY-145306
    DX3-234

    		Oxidative Phosphorylation Mitochondrial Metabolism Cancer
    DX3-234 is an oxidative phosphorylation (OXPHOS) inhibitor. DX3-234 shows significant tumor suppression in the Pan02 syngeneic model of pancreatic cancer .
    DX3-234
  • HY-P5837
    Citrullinated LL-37 2cit

    		Interleukin Related Enterovirus Inflammation/Immunology
    Citrullinated LL-37 2cit is a citrullinated LL-37 (HY-P1222) peptide. Citrullinated LL-37 2cit reduces LL-37 activity against HRV at 10 μg/mL and reduces the antibacterial effect of LL-37. Citrullinated LL-37 2cit causes a reduction in the levels of IL-8, CCL5, and IL-6 mRNA induced by RV1B. Citrullinated LL-37 2cit shows a moderate loss in the ability to reduce HRV-induced CCL5 secretion .
    Citrullinated LL-37 2cit
  • HY-P5843
    Citrullinated LL-37 4cit

    		Enterovirus Infection
    Citrullinated LL-37 3cit is a citrullinated LL-37 (HY-P1222) peptide. Citrullinated LL-37 3cit lacks all antiviral activity at 10 μg/mL and retains some activity against HRV at 30 μg/mL. Citrullinated LL-37 3cit reduces the immunomodulatory activity of LL-37. Citrullinated LL-37 3cit shows a moderate loss in the ability to reduce HRV-induced CCL5 secretion .
    Citrullinated LL-37 4cit
  • HY-175361
    RORγ agonist 2

    		ROR Cancer
    RORγ agonist 2 (Compound 34) is a selective RORγ agonist with an EC50 of 0.03  μM for hRORγ. RORγ agonist 2 significantly inhibits tumors growth in syngeneic MC38 tumor mice model .
    RORγ agonist 2
  • HY-P5838
    Citrullinated LL-37 5cit

    		Bacterial Inflammation/Immunology
    Citrullinated LL-37 5cit is a citrullinated LL-37 (HY-P1222) peptide. The antiviral and antibacterial effects of Citrullinated LL-37 5cit are significantly reduced compared to native LL-37. Citrullinated LL-37 5cit is unable to reduce LPS-mediated release of TNF-α due to a lack of LPS-binding capacity .
    Citrullinated LL-37 5cit
  • HY-P5836
    Citrullinated LL-37 1cit

    		Interleukin Related Bacterial Enterovirus Inflammation/Immunology
    Citrullinated LL-37 1cit is a citrullinated LL-37 (HY-P1222) peptide. Citrullinated LL-37 1cit does not alter the antiviral effect of LL-37 toward human rhinovirus. Citrullinated LL-37 1cit shows antibacterial activity toward S. aureus. Citrullinated LL-37 1cit causes a reduction in the levels of IL-8, CCL5, and IL-6 mRNA induced by RV1B .
    Citrullinated LL-37 1cit
  • HY-P4744A
    LL-37 amide TFA
    1 Publications Verification

    		 Bacterial Infection Cancer
    LL-37 amide TFA is a positively charged antimicrobial peptide. LL-37 amide TFA has anticancer activity and can be used for cancer research [2].
    LL-37 amide TFA
  • HY-P1884
    LL-37, acetylated,amidated

    		Bacterial Infection
    LL-37, acetylated, amidated is a cathelicidin peptide LL-37 acetylated on the N-terminus and amidated on the C-terminus. The single human cathelicidin peptide LL-37 has antimicrobial and anti-biofilm activity against multiple Gram-positive and Gram-negative human pathogens, and has wound-healing effects on the host .
    LL-37, acetylated,amidated
  • HY-P4836A
    LL-37 FK-13 TFA

    		Parasite Infection
    LL-37 FK-13 TFA is the TFA salt form of LL-37 FK-13 (HY-P4836). LL-37 FK-13 TFA is an antimicrobial agent, that inhibits Trichomonas vaginalis. LL-37 FK-13 TFA exhibits minimal hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts .
    LL-37 FK-13 TFA
  • HY-P5391
    LL-37(17-32)

    		Bacterial Others
    LL-37(17-32) is a biological active peptide. (This peptide is an active segment of LL-37, a peptide derived from the C-terminal domain of human cathelicidin antimicrobial peptide. It has been reported that the LL17-32 peptide exhibits reversal effect on ABCG2-mediated multidrug resistance in cancer cell lines.)
    LL-37(17-32)
  • HY-P1222
    LL-37, human
    4 Publications Verification

    		 Bacterial Infection
    LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human could help protect the cornea from infection and modulates wound healing [2] .
    LL-37, human
  • HY-P1222B
    LL-37, human acetate
    4 Publications Verification

    		 Bacterial Infection Inflammation/Immunology
    LL-37, human acetate is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human acetate could help protect the cornea from infection and modulates wound healing [2] .
    LL-37, human acetate
  • HY-P5057
    5-FAM-LL-37

    		Fluorescent Dye Bacterial Others
    5-FAM-LL-37 is afluorescent labeled LL-37, human (HY-P1222).
    5-FAM-LL-37
  • HY-P4836
    LL-37 FK-13

    		Parasite Infection
    LL-37 FK-13 is an antimicrobial agent, that inhibits Trichomonas vaginalis. LL-37 FK-13 exhibits slight hemolytic effects on human erythrocytes and low cytotoxicity to human fibroblasts .
    LL-37 FK-13
  • HY-128464
    LL320

    		Others Metabolic Disease
    LL320 is a selective NNMT inhibitor with a Ki,app of 6.8 nM. LL320 exhibits interactions with RNMT, DPH5, and SAHH .
    LL320
  • HY-P4799
    LL-37 KR20

    		Drug Derivative Others
    LL-37 KR20 is aLL 37 derivative.
    LL-37 KR20
  • HY-P5057A
    5-FAM-LL-37 TFA

    		Fluorescent Dye Bacterial Infection
    5-FAM-LL-37 TFA is the TFA salt form of 5-FAM-LL-37 (HY-P5057). 5-FAM-LL-37 TFA is a LL-37 peptide labeled with fluorescein, which retains the antibacterial and immunomodulatory activities of LL-37. 5-FAM-LL-37 TFA binds to the bacterial cell membrane, destroys the integrity of the membrane, and exhibits board-spectrum antibacterial efficacy .
    5-FAM-LL-37 TFA
  • HY-18234B
    Leupeptin Ac-LL

    		Ser/Thr Protease Metabolic Disease Inflammation/Immunology Cancer
    Leupeptin Ac-LL is a protease inhibitor from actinomycetes. Leupeptin Ac-LL has antiplasmin activity .
    Leupeptin Ac-LL
  • HY-14990A
    Sudoterb hydrochloride

    LL 3858 hydrochloride

    		 Bacterial Infection
    Sudoterb (LL 3858) hydrochloride is an orally active anti-Tuberculosis agent .
    Sudoterb hydrochloride
  • HY-14990
    Sudoterb

    LL 3858

    		 Bacterial Infection
    Sudoterb (LL 3858) is an orally active anti-Tuberculosis agent .
    Sudoterb
  • HY-P1222A
    LL-37, human TFA
    4 Publications Verification

    		 Bacterial Infection
    LL-37, human TFA is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity. LL-37, human TFA could help protect the cornea from infection and modulates wound healing [2] .
    LL-37, human TFA
  • HY-P10306
    Cys-LL37

    		Bacterial Infection
    Cys-LL37 is a biomaterial with antimicrobial properties developed by covalently fixing to the surface of titanium. Cys-LL37 uses a flexible hydrophilic polyethylene glycol spacer and selective n-terminal coupling LL37, a surface peptide layer that kills bacteria on contact is formed. Cys-LL37 can be used in research to develop new antimicrobial biomaterials .
    Cys-LL37
  • HY-P5842
    Citrullinated LL-37 3cit

    		Bacterial Influenza Virus Infection
    Citrullinated LL-37 3cit is a host defense peptide (HDP) with broad immunomodulatory and antimicrobial activities. Citrullinated LL-37 3cit exhibits direct antiviral effects against human rhinoviruses (HRV) .
    Citrullinated LL-37 3cit
  • HY-120349
    LL-Z1640-4

    		p38 MAPK JNK Apoptosis Reactive Oxygen Species (ROS) Cancer
    LL-Z1640-4 is a potent p38/JNK signaling inhibitor. LL-Z1640-4 significantly diminishes p38 and JNK activation in HCC cells transfected with MLK4 siRNA. LL-Z1640-4 markedly attenuates ROS production induced by MLK4 knockdown. LL-Z1640-4 significantly reduces the apoptotic cells in HCC cells transfected with siMLK4 [2].
    LL-Z1640-4
  • HY-P5057B
    5-FAM-Ahx-LL-37 TFA

    		Fluorescent Dye Bacterial Infection
    5-FAM-Ahx-LL-37 TFA is a 5-FAM (HY-66022) labeled LL-37, human (HY-P1222). The carboxyfluorescein group is attached via a 6-carbon spacer, 6-Aminohexanoic acid (Ahx, HY-B0236). LL-37, human is a 37-residue, amphipathic, cathelicidin-derived antimicrobial peptide, which exhibits a broad spectrum of antimicrobial activity .
    5-FAM-Ahx-LL-37 TFA
  • HY-136828
    LL-BM123α

    		Antibiotic Bacterial Infection
    LL-BM123α is a basic antibiotic isolated from Nocardia sp. LL-BM123α exhibits moderate activity against Gram-negative bacteria.
    LL-BM123α
  • HY-156084
    LL-K9-3

    		CDK PROTACs Apoptosis c-Myc Cancer
    LL-K9-3 is a potent small-molecule degrader of CDK9-cyclin T1. LL-K9-3 has anti-proliferative and pro-apoptotic activities and suppresses downstream signaling of CDK9 and AR. Moreover, LL-K9-3 inhibits AR and Myc-driven oncogenic transcriptional programs .
    LL-K9-3
  • HY-136954
    LL-BM123γ2

    		Bacterial Infection
    LL-BM123γ2 is an antibacterial agent which is active against a variety of microorganisms. LL-BM123γ2 can be used for antibacterial research .
    LL-BM123γ2
  • HY-149209
    LL-K8-22

    		PROTACs CDK STAT Early 2 Factor (E2F) Cancer
    LL-K8-22 is a potent, selective and durable PROTAC CDK8-cyclin C dual degrader, with DC50 values of 2.52 and 2.64 μM, respectively. LL-K8-22 also suppresses STAT1 Ser 727 phosphorylation. LL-K8-22 inhibits E2F- and MYC-driven carcinogenic transcriptional programs. LL-K8-22 can be used for triplenegative breast cancer (TNBC) research. (Pink: Ligand for target protein (HY-168683); Black: Linker (HY-Y0340); Blue: Ligand for E3 ligase (HY-N2427)) .
    LL-K8-22
  • HY-114749
    LL-C 10037α

    		Antibiotic Bacterial Infection Cancer
    LL-C 10037α is an antitumor antibiotic and can be isolated from Streptomyces .
    LL-C 10037α
  • HY-115843
    LL-D05139β

    		Antibiotic Bacterial Infection Cancer
    LL-D05139β is a potent antibacterial antibiotic and antitumor agent .
    LL-D05139β
  • HY-163944
    LL-K12-18

    		Molecular Glues CDK Cancer
    LL-K12-18 is a two-site molecular glue that enhances the protein-protein interaction of the CDK12-DDB1 complex, stabilizing the CDK12-DDB1 complex and promoting the degradation of cyclin K (EC50=0.37 nM). LL-K12-18 exhibits strong gene transcription inhibition and anti-proliferation effects in tumor cells. LL-K12-18 can be used in cancer research .
    LL-K12-18
  • HY-130214
    7-Hydroxypestalotin

    LL-P880β

    		 Endogenous Metabolite Others
    7-Hydroxypestalotin (LL-P880β) is a fungal metabolite .
    7-Hydroxypestalotin
  • HY-145239
    PD-1/PD-L1-IN-13

    		PD-1/PD-L1 Cancer
    PD-1/PD-L1-IN-13 (Compound 43) is a potent immune checkpoint PD-1/PD-L1 inhibitor with an IC50 value of 10.2 nM. PD-1/PD-L1-IN-13 promots CD8 + T cell activation and delays the tumor growth in the Hepa1-6 syngeneic mouse model .
    PD-1/PD-L1-IN-13
  • HY-109963
    PR5-LL-CM01

    		Histone Methyltransferase Cancer
    PR5-LL-CM01 is a potent protein arginine methyltransferase 5 (PRMT5) inhibitor (IC50= 7.5 μM). Anti-tumor activies .
    PR5-LL-CM01
  • HY-114708
    Ilicicolin B

    LL-Z 1272β

    		 Bacterial Infection Cancer
    Ilicicolin B (LL-Z 1272β) inhibits Bacillus carbonifera with the concentration of 6 μg/mL and its toxic concentration to Hela cells is 0.3 μg/mL .
    Ilicicolin B
  • HY-113561
    Biphenomycin A

    LL-AF283α

    		 Antibiotic Bacterial Infection
    Biphenomycin A (LL-AF283α) is a cyclic peptide antibiotic that can be found in Streptomyces griseorubiginosus 43708. It has antibacterial activity and can be used in research in the field of anti-infection .
    Biphenomycin A
  • HY-178716
    PTPN2/1-IN-4

    		Phosphatase IFNAR STAT JAK Cancer
    PTPN2/1-IN-4 (Compound WS35) is an orally active, dual-functional inhibitor of PTPN1 and PTPN2 with IC50s of 12.8 and 5.8 nM for PTPN1 and PTPN2, respectively. PTPN2/1-IN-4 modulates the IFNγ-JAK-STAT signaling pathway and significantly augments CD8 + T-cell tumor infiltration. PTPN2/1-IN-4 has potent anticancer activity, robustly inhibiting tumor growth both as a monotherapy and in combination with an anti-PD-1 antibody in B16-OVA syngeneic mouse models .
    PTPN2/1-IN-4

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