2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. nAChR
  4. Anti-Human/Rat/Fish AChR Antibody (Mab35)

Anti-Human/Rat/Fish AChR Antibody (Mab35) 

Cat. No.: HY-P990302 Purity: 95.00%
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Anti-Human/Rat/Fish AChR Antibody (Mab35) is an anti-human/rat/fish AChR IgG1 monoclonal antibody. Anti-Human/Rat/Fish AChR Antibody (Mab35) can attack the AChR of neuromuscular junctions. Anti-Human/Rat/Fish AChR Antibody (Mab35) can be used for the construction of myasthenia gravis models.

For research use only. We do not sell to patients.

Anti-Human/Rat/Fish AChR Antibody (Mab35) Chemical Structure

Anti-Human/Rat/Fish AChR Antibody (Mab35) Chemical Structure

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Description

Anti-Human/Rat/Fish AChR Antibody (Mab35) is an anti-human/rat/fish AChR IgG1 monoclonal antibody. Anti-Human/Rat/Fish AChR Antibody (Mab35) can attack the AChR of neuromuscular junctions. Anti-Human/Rat/Fish AChR Antibody (Mab35) can be used for the construction of myasthenia gravis models[1][2][3].

Isotype

Rat IgG1 kappa
Recommend Isotype Controls
IC50 & Target

AChR
In Vitro

Anti-Human/Rat/Fish AChR Antibody (Mab35) (10 nM, 24 h) significantly inhibits the secretion of catecholamines in bovine adrenal chromaffin cells[2].
Anti-Human/Rat/Fish AChR Antibody (Mab35) specifically binds to the α1, α3, and α5 subunits of nAChR in TIB-175 hybridoma cells[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Human/Rat/Fish AChR Antibody (Mab35) Related Antibodies
In Vivo

Anti-Human/Rat/Fish AChR Antibody (Mab35) (1 mg/kg, i.v., on the seventh day after injection of C5 siRNA/LNP) successfully constructs the myasthenia gravis (MG) model in female Lewis rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Female Lewis rats[1]
Dosage: 1 mg/kg
Administration: Intravenous injection (i.v.), on the seventh day after injection of C5 siRNA/LNP
Result: Caused weight loss in rats.
Reduced fore limb grip strength, hindlimb weakness, and partial paralysis on days 8 and 9.
Gene ID

1138  [NCBI]

Accession

P30532 / NP_000736.2
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Human/Rat/Fish AChR Antibody (Mab35)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Human/Rat/Fish AChR Antibody (Mab35) Related Classifications

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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Human/Rat/Fish AChR Antibody (Mab35)nAChRNicotinic acetylcholine receptorsAChRmyasthenia gravisMGInhibitorinhibitorinhibit

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