Anti-infective agent 12 

Anti-infective agent 12 (Compound A09) is a competitive inhibitor of type I signal peptidease (SPase I), with an IC₅₀ of 4.475 μM and a K_d of 16.3 μM. Anti-infective agent 12 has the ability to disrupt bacterial membranes and remove biofilms. Anti-infective agent 12 exhibits potent bactericidal activity against Gram-positive bacteria, with MIC values of 4, 4, 8, and 8 μg/mL for Staphylococcus aureus, Enterococcus faecalis, Enterococcus faecium, and Streptococcus suis, respectively. Anti-infective agent 12 remains effective against multi-drug resistant strains, but has weaker activity against Gram-negative bacteria (such as Escherichia coli and Salmonella), with MIC values > 64 μg/mL. Anti-infective agent 12 has low hemolytic activity and shows significant efficacy in mouse skin infection models. Anti-infective agent 12 reduces the risk of drug resistance caused by single-target mutations. Anti-infective agent 12 can be used to study infections caused by multi-drug resistant Gram-positive bacteria^[1].

637.81

C₃₅H₅₁N₅O₆

O=C(O)C1=CC=CC=C1NC([C@@H](NC(CNC(C2=CC(CN)=CC=C2NC(CCCCCCCCCCC)=O)=O)=O)CC(C)C)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Lu X, et al. Dual-targeting amphiphilic lipopeptides combat multidrug-resistant Gram-positive pathogens by inhibiting type I signal peptidase and disrupting bacterial membrane. Eur J Med Chem. 2026 Jan 5;301:118244.