2. Apoptosis Cell Cycle/DNA Damage
  3. MDM-2/p53 Apoptosis Checkpoint Kinase (Chk)
  4. p53 Stabilizer 2

p53 Stabilizer 2 (Compound 17a16) is a p53 stabilizer. p53 Stabilizer 2 induces S-phase arrest and apoptosis in both p53-proficient and p53-deficient cancer cells. p53 Stabilizer 2 induces mitochondrial stress and activates two checkpoint pathways: NA-PKcs-dependent p53 stabilization and ATR-Chk1 axis activation. p53 Stabilizer 2 inhibits tumor growth in p53-deficient xenograft model.

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p53 Stabilizer 2 Chemical Structure

p53 Stabilizer 2 Chemical Structure

CAS No. : 2531685-87-5

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p53 Stabilizer 2 Related Antibodies

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Description

p53 Stabilizer 2 (Compound 17a16) is a p53 stabilizer. p53 Stabilizer 2 induces S-phase arrest and apoptosis in both p53-proficient and p53-deficient cancer cells. p53 Stabilizer 2 induces mitochondrial stress and activates two checkpoint pathways: NA-PKcs-dependent p53 stabilization and ATR-Chk1 axis activation. p53 Stabilizer 2 inhibits tumor growth in p53-deficient xenograft model[1].

Molecular Weight

602.58

Formula

C30H37NO7Se
CAS No.
SMILES

O=C1O[C@H]([C@@H]2N(C)CCC3=C(C[Se]C4CCCCCC4)C5=C(OCO5)C(OC)=C23)C6=C1C(OC)=C(OC)C=C6
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p53 Stabilizer 2 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

p53 Stabilizer 22531685-87-5MDM-2/p53ApoptosisCheckpoint Kinase (Chk)p53 stabilizationATR-Chk1 axis activationtumorp53-deficientxenograftInhibitorinhibitorinhibit

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