2. Apoptosis
  3. Necroptosis RIP kinase
  4. AZ'320

AZ'320 is an ATP-competitive necroptosis (EC50 of 4.9 μM) inhibitor and a RIPK1 (pKD of 5.45) inhibitor. AZ'320 inhibits necroptosis by inhibiting RIPK1 phosphorylation. AZ’320 prevents mortality of the mice and rescues temperature and body weight in SIRS mice models. AZ'320 can be used for researchs of cancer and inflammation.

For research use only. We do not sell to patients.

AZ'320 Chemical Structure

AZ'320 Chemical Structure

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

AZ'320 Related Antibodies

Top Publications Citing Use of Products

View All RIP kinase Isoform Specific Products:

View All Isoforms
RIPK1 RIPK2 RIPK3

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

AZ'320 is an ATP-competitive necroptosis (EC50 of 4.9 μM) inhibitor and a RIPK1 (pKD of 5.45) inhibitor. AZ'320 inhibits necroptosis by inhibiting RIPK1 phosphorylation. AZ’320 prevents mortality of the mice and rescues temperature and body weight in SIRS mice models. AZ'320 can be used for researchs of cancer and inflammation[1].

In Vitro

AZ’320 (0.1-10 μM, 4 h) dose-dependently inhibits the levels of RIPK1 Ser166 phosphorylation in I2.1 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

AZ'320 Related Antibodies

Western Blot Analysis[1]

Cell Line: I2.1 FADD−/− human Jurkat cells
Concentration: 01, 1, 5 and 10 μM
Incubation Time: 4 h
Result: Dose-dependently inhibited the levels of RIPK1 Ser166 phosphorylation.
In Vivo

AZ’320 (5 mg/kg, i.v., 15 min before TNF stimulation) prevents mortality of the mice and rescues temperature and body weight to a similar degree as Nec-1 (HY-15760) in SIRS mice models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Systemic inflammatory response syndrome (SIRS) mice models (C57BL/6, male, 6-8 weeks)[1]
Dosage: 5 mg/kg
Administration: Intravenously injection, 15 min before 96 h of 0.5 mg/kg TNF stimulation
Result: Prevented mortality of the mice and rescued temperature and body weight to a similar degree as Nec-1 (HY-15760).
Molecular Weight

416.51

Formula

C20H20N2O4S2
SMILES

O=S(C1=CC=C(C2=CC=C3C=CC=NC3=C2)C=C1)(N4CC(CS(=O)(C)=O)C4)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

AZ'320 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AZ'320NecroptosisRIP kinaseReceptor-interacting protein kinasesRIPKReceptor-interacting kinase 1 (RIPK1)I2.1 FADD?/? human Jurkat cellsSystemic inflammatory response syndrome (SIRS)Inhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
AZ'320
Cat. No.:
HY-174820
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.