2. PI3K/Akt/mTOR
  3. PI3K Akt
  4. AS-605240 potassium

AS-605240 (potassium) is an orally active PI3Kγ inhibitor (IC50: 8 nM; Ki: 7.8 nM). AS-605240 (potassium) inhibits MCP-1- and CSF1-induced PKB phosphorylation (IC50 values are 0.181 and 0.550 µM, respectively). AS-605240 (potassium) reduces neutrophil recruitment in RANTES (CCL5)- and thioglycolate-induced peritonitis mouse models (EC50 values are 9.1 and 10 mg/kg, respectively). AS-605240 (potassium) ameliorates αCII-IA-induced arthritis in mice.

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AS-605240 potassium Chemical Structure

AS-605240 potassium Chemical Structure

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AS-605240 potassium Related Antibodies

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Description

AS-605240 (potassium) is an orally active PI3Kγ inhibitor (IC50: 8 nM; Ki: 7.8 nM). AS-605240 (potassium) inhibits MCP-1- and CSF1-induced PKB phosphorylation (IC50 values are 0.181 and 0.550 µM, respectively). AS-605240 (potassium) reduces neutrophil recruitment in RANTES (CCL5)- and thioglycolate-induced peritonitis mouse models (EC50 values are 9.1 and 10 mg/kg, respectively). AS-605240 (potassium) ameliorates αCII-IA-induced arthritis in mice[1].

IC50 & Target[1]

PI3Kγ

8 nM (IC50)

Molecular Weight

295.36

Formula

C12H6KN3O2S
SMILES

O=C([N-]C/1=O)SC1=C/C2=CC3=C(N=CC=N3)C=C2.[K+]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AS-605240 potassium Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AS-605240AS605240AS 605240PI3KAktPhosphoinositide 3-kinasePKBProtein kinase BMCP-1CSF1peritonitis mouse modelarthritisBMDMsInhibitorinhibitorinhibit

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