2. Membrane Transporter/Ion Channel Neuronal Signaling Anti-infection Immunology/Inflammation NF-κB MAPK/ERK Pathway Metabolic Enzyme/Protease Cell Cycle/DNA Damage
  3. TRP Channel Bacterial Fungal NO Synthase COX NF-κB p38 MAPK Keap1-Nrf2 Heme Oxygenase (HO) PERK JNK Calcium Channel
  4. Pulegone

Pulegone is a monoterpene ketone compound widely present in the essential oils of many plants. Pulegone can also be used as a bird repellent. Pulegone has multiple activities such as anti-inflammatory, antibacterial, antifungal, and anti-hyperalgesic effects. Pulegone is particularly effective against bacteria of the Salmonella species.

For research use only. We do not sell to patients.

Pulegone Chemical Structure

Pulegone Chemical Structure

CAS No. : 89-82-7

Size Price Stock Quantity
Solution
10 mM * 1 mL in DMSO In-stock
Liquid
500 mg In-stock
1 g In-stock
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10 g   Get quote  

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Based on 1 publication(s) in Google Scholar

Other Forms of Pulegone:

Pulegone Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Pulegone

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TRPC TRPM TRPV TRPA TRPML

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nNOS iNOS eNOS

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COX COX-1 COX-2 COX-3

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NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

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p38 MAPK p38α p38β MAPK13 p38δ p38γ

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HO-1 HO-2

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JNK1 JNK2 JNK3 JNK

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

Pulegone is a monoterpene ketone compound widely present in the essential oils of many plants. Pulegone can also be used as a bird repellent. Pulegone has multiple activities such as anti-inflammatory, antibacterial, antifungal, and anti-hyperalgesic effects. Pulegone is particularly effective against bacteria of the Salmonella species[1][2][3][4][5].

In Vitro

Pulegone (6.25-50 µg/mL; 20-26 h) can inhibit the expression of inflammatory mediators by downregulating the iNOS, COX-2, NF-κB, and MAPK signaling pathways and upregulating Nrf-2/HO-1 in LPS (HY-D1056)-stimulated RAW264.7 cells[1].
Pulegone (0.01-3 mM; 0-5 min) can increase the intracellular Ca2+ concentration in chicken sensory neurons[2].
Pulegone (0.01-3 mM; 0-5 min) can activate TRPM8 and TRPA1 and inhibit TRPM8 at high concentrations (1 mM and above) in HEK293 cells expressing chicken TRPM8, TRPA1, and TRPV1[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Pulegone Related Antibodies

Western Blot Analysis[1]

Cell Line: LPS (HY-D1056)-stimulated RAW264.7 cells.
Concentration: 6.25, 12.5, 25 and 50 µg/mL
Incubation Time: Pretreated with 2 h, then co-incubation for 18 h
Result: Inhibited the expression of iNOS, COX-2 and NF-κB.
Downregulated phosphorylation of ERK, JNK, and p38.
In Vivo

Pulegone (100 mM; intraplantar injection; single dose) can induce pain-related behaviors in chicks, but these behaviors can be inhibited by a TRPA1 antagonist[2].
Pulegone (10-150 mg/kg; intraperitoneal injection; single dose) has a beneficial effect in a rat model of inflammatory pain[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male Wistar rats (300 g) treated Complete Freund's adjuvant (HY-153808)[3].
Dosage: 10, 50, 100 and 150 mg/kg
Administration: Intraperitoneal injection; single dose
Result: Exerted an anti-hyperalgesic effect, increased the mechanical threshold, thermal heat threshold and decreased the thermal cold score at dose of 100 mg/kg.
Was devoid of in vivo locomotor side effects.
Molecular Weight

152.24

Formula

C10H16O
CAS No.
Appearance

Liquid (Density: 0.937 g/cm3)

Color

Colorless to light yellow

SMILES

O=C1/C(CC[C@@H](C)C1)=C(C)/C
Structure Classification
Initial Source
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Pure form -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Purity & Documentation
References
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Pulegone Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Pulegone89-82-7TRP ChannelBacterialFungalNO SynthaseCOXNF-κBp38 MAPKKeap1-Nrf2Heme Oxygenase (HO)PERKJNKCalcium ChannelTransient receptor potential channelsNitric oxide synthasesNOSCyclooxygenaseNuclear factor-κBNuclear factor-kappaBHeme OxygenaseProtein kinase R-like endoplasmic reticulum kinasePKR-like endoplasmic reticulum kinasec-Jun N-terminal kinaseCa2+ channelsCa channelsinflammatory pain model RAW264.7 cellschicken sensory neuronsInhibitorinhibitorinhibit

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