2. Immunology/Inflammation NF-κB
  3. Interleukin Related NF-κB
  4. MOR-106

MOR-106  (Synonyms: MOR12743; MOR03207)

Cat. No.: HY-P991598
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MOR-106 (MOR12743) is a humanized anti-IL-17C IgG1 monoclonal antibody. MOR-106 inhibits the NF-κB signaling pathway by specifically binding to IL-17C (IC50 = 59 pM for human IL-17C, IC50 = 55 pM for mouse IL-17C). MOR-106 can effectively inhibit skin inflammation and reduce related inflammatory factors in animal models of psoriasis and atopic dermatitis.

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MOR-106 Chemical Structure

MOR-106 Chemical Structure

CAS No. : 2304625-87-2

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MOR-106 Related Antibodies

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Description

MOR-106 (MOR12743) is a humanized anti-IL-17C IgG1 monoclonal antibody. MOR-106 inhibits the NF-κB signaling pathway by specifically binding to IL-17C (IC50 = 59 pM for human IL-17C, IC50 = 55 pM for mouse IL-17C). MOR-106 can effectively inhibit skin inflammation and reduce related inflammatory factors in animal models of psoriasis and atopic dermatitis[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
IC50 & Target[1][2]

NF-κB

 

IL-17C

 

In Vitro

MOR-106 (0.00001-1 nM, 30 min) potently blocks the interaction of human (IC50 = 59 pM) and mouse (IC50 = 55 pM) IL-17C to IL-17RE[1].
MOR-106 (0.0001-1 μg/mL, 30 min) significantly inhibits IL-17C induced activation of NF-κB signaling pathway in NIH3T3 cells[1].
MOR-106 (0.001-1 μg/mL, 48 h) significantly inhibits the expression of DEFB4A and CSF3 induced by IL-17C and TNF-α in human and mouse primary keratinocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MOR-106 Related Antibodies

RT-PCR[1]

Cell Line: human and mouse primary keratinocytes
Concentration: 0.001-1 μg/mL
Incubation Time: 48 h
Result: Significantly reduced the level of DEFB4A and CSF3.
In Vivo

MOR-106 (10 mg/kg, i.p., 3 days before and just before the first injection of IL-23) significantly reduces IL-23-induced skin inflammation in female BALB/c mice[1].
MOR-106 (0.4-50 mg/kg, i.p., 3 days before, at the start, and 4 days after the first application of MC903) effectively alleviates MC903 induced atopic dermatitis and atopic eczema in female BALB/c mice[1][2].
MOR-106 (3 and 30 mg/kg, i.p., twice weekly, for 6 weeks) alleviates spontaneous atopic dermatitis in Flaky tail mice[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: IL-23 (1 μg, for 4 consecutive days) injeceted female BALB/c mice (8 weeks)[1]
Dosage: 10 mg/kg
Administration: Intraperitoneal injection (i.p.), 3 days before and just before the first injection of IL-23
Result: Significantly reduced ear swelling and epidermal thickening.
Reduced the expression of inflammatory factors such as IL-17A, IL-22, IL-1β, LCN2, S100A8 and S100A9.
Animal Model: Topical administration of 2 nM MC903 (HY-10001) for 5 days to female BALB/c mice (8 weeks)[1][2]
Dosage: 0.4, 2, 10 and 50 mg/kg
Administration: Intraperitoneal injection (i.p.), 3 days before, at the start, and 4 days after the first application of MC903
Result: Dose dependently reduced ear swelling and epidermal thickening.
Reduced TSLP, IL-33, and CCL17 levels.
Significantly reduced skin infiltration of T cells, eosinophils, and neutrophils.
Animal Model: Flaky tail mice on a congenic C57BL/6J background[1]
Dosage: 3 and 30 mg/kg
Administration: Intraperitoneal injection (i.p.), twice weekly for 6 weeks
Result: Significantly reduced skin inflammation score.
Reduced the number of mast cells and serum IgE levels.
Reduced the expression of IL-4, IL-17A, CCL17 and IFN-γ.
Gene ID

27189  [NCBI]

Accession
Target

IL-17C
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
CAS No.
SMILES

N/A
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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MOR-106 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MOR-1062304625-87-2MOR12743 MOR03207MOR106MOR 106MOR 12743MOR-12743MOR03207MOR 03207MOR-03207Interleukin RelatedNF-κBILNuclear factor-κBNuclear factor-kappaBIL-17Cpsoriasisatopic dermatitisInflammationInhibitorinhibitorinhibit

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