2. GPCR/G Protein Neuronal Signaling
  3. Orexin Receptor (OX Receptor)
  4. Orexin 2 Receptor Agonist 3

Orexin 2 Receptor Agonist 3 is an orally active and brain-penetrant orexin receptor type-2 (OX2) agonist (EC50: 2.5 nM). Orexin 2 Receptor Agonist 3 increases wakefulness in the orexin/ataxin-3 NT1 mouse model and healthy beagle dogs. Orexin 2 Receptor Agonist 3 can be used in the study of narcolepsy.

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Orexin 2 Receptor Agonist 3 Chemical Structure

Orexin 2 Receptor Agonist 3 Chemical Structure

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Orexin 2 Receptor Agonist 3 Related Antibodies

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Description

Orexin 2 Receptor Agonist 3 is an orally active and brain-penetrant orexin receptor type-2 (OX2) agonist (EC50: 2.5 nM). Orexin 2 Receptor Agonist 3 increases wakefulness in the orexin/ataxin-3 NT1 mouse model and healthy beagle dogs. Orexin 2 Receptor Agonist 3 can be used in the study of narcolepsy[1].

IC50 & Target[1]

OX2

2.5 nM (EC50)

Molecular Weight

537.56

Formula

C27H29F2N7O3
SMILES

FC1=CC([C@H](C(NC2(C3)CC3(C)C2)=O)N(C4CC5(CC5)C4)C(CC6=C(C7=NN(C)N=N7)ON=C6)=O)=C(F)C=C1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Orexin 2 Receptor Agonist 3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Orexin 2 Receptor Agonist 3Orexin Receptor (OX Receptor)Hypocretin ReceptorHCRT Receptornarcolepsyorexin/ataxin-3 NT1 mouse modelHEK-293 cellsInhibitorinhibitorinhibit

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