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  2. Immunology and Inflammatory Disease Models
  3. Myocarditis Models
  4. Myosin H Chain Fragment, mouse acetate

Myosin H Chain Fragment, mouse acetate salt is a fragment of the α-Myosin heavy chain peptide. Myosin H Chain Fragment can be used to induce experimental autoimmune myocarditis (EAM) mouse model.

For research use only. We do not sell to patients.

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Myosin H Chain Fragment, mouse acetate Chemical Structure

Myosin H Chain Fragment, mouse acetate Chemical Structure

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Description

Myosin H Chain Fragment, mouse acetate salt is a fragment of the α-Myosin heavy chain peptide. Myosin H Chain Fragment can be used to induce experimental autoimmune myocarditis (EAM) mouse model[1][2].

In Vivo

Note:
Please do not refer to only one article to determine the experimental conditions. It is recommended to determine the optimal experimental conditions (animal strain, age, dosage, frequency and cycle, detection time and indicators, etc.) through preliminary experiments before the formal experiment.

Myosin H Chain Fragment, mouse can be used in animal modeling to create myocarditis models[1][3].

Induction of Myocarditis[1][2]
Background
Myosin H Chain Fragment, mouse causes myocarditis by inducing cardiac inflammation, triggering an autoimmune response and increasing leukocyte infiltration.
Specific Modeling Methods
Mice: Balb/c • male • 6-8 weeks old
Administration: 150 μg • s.c. • days 0 and 7
Note
(1) Mice were divided into 2 groups, the control group contained 10 mice, and the Myosin H Chain Fragment, mouse induced group included 12 mice.
(2) Echocardiography was performed on days 0, 7, and 21 using an anaesthesia system under continuous 2%-3% isoflurane anaesthesia, and the temperature of the mice was adjusted to 37 ± 0.5 °C using a heating pad and rectal probe.
(3) Mice were executed 21 days after drug administration, and the hearts were immediately excised and cut along the short axis of the left ventricle at the level of the middle ventricle, then fixed overnight in 4% formaldehyde, paraffin sections were prepared and stained with hematoxylin and eosin for histopathological examination.
Modeling Indicators
Organizational changes: A marked inflammatory infiltrate was present, with a significant increase in left ventricular thickness.
Echocardiography: Decreased left ventricular systolic function and increased left ventricular internal diastolic diameter (LVIDd) and systolic internal diameter (LVID).
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MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Molecular Weight

2073.37 (free acid)

Formula

C91H149N25O28S.xC2H4O2

Sequence

Ac-Arg-Ser-Leu-Lys-Leu-Met-Ala-Thr-Leu-Phe-Ser-Thr-Tyr-Ala-Ser-Ala-Asp-Arg

Sequence Shortening

Ac-RSLKLMATLFSTYASADR

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

Please store the product under the recommended conditions in the Certificate of Analysis.

Purity & Documentation
References
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Product Name:
Myosin H Chain Fragment, mouse acetate
Cat. No.:
HY-P2464A
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