2. Metabolic Enzyme/Protease Apoptosis Anti-infection NF-κB
  3. Heme Oxygenase (HO) Apoptosis Bcl-2 Family Caspase Cytochrome P450 Bacterial Keap1-Nrf2
  4. Co(III) protoporphyrin IX chloride

Co(III) protoporphyrin IX chloride  (Synonyms: Protoporphyrin IX cobaltic chloride; CoPPIX-Cl)

Cat. No.: HY-W250116 Purity: ≥95.0%
COA
SDS
Handling Instructions Technical Support

Co(III) protoporphyrin IX chloride (Protoporphyrin IX cobaltic chloride) is an inducer of HO-1. Co(III) protoporphyrin IX chloride has activities such as anti-inflammation and antibacterial properties. Co(III) protoporphyrin IX chloride can also be used in the research of ischemia-reperfusion injury models.

For research use only. We do not sell to patients.

Co(III) protoporphyrin IX chloride Chemical Structure

Co(III) protoporphyrin IX chloride Chemical Structure

CAS No. : 102601-60-5

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Based on 1 publication(s) in Google Scholar

Co(III) protoporphyrin IX chloride Related Antibodies

Top Publications Citing Use of Products

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HO-1 HO-2

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Bcl-2 Bcl-xL Bcl-W Mcl-1 Bfl-1 Bcl-B Bax Bak Bim BNIP3

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Caspase 1 Caspase 2 Caspase 3 Caspase 4 Caspase 5 Caspase 6 Caspase 7 Caspase 8 Caspase 9 Caspase 10 Caspase 12 Caspase Caspase 11 Caspase-13

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CYP1 CYP2 CYP3 CYP4 CYP11 CYP17 Aromatase/CYP19A1 CYP26 CYP51 CYP1A2 CYP2D6 CYP2C9 CYP2C19 CYP3A4 CYP17A1

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Co(III) protoporphyrin IX chloride (Protoporphyrin IX cobaltic chloride) is an inducer of HO-1. Co(III) protoporphyrin IX chloride has activities such as anti-inflammation and antibacterial properties. Co(III) protoporphyrin IX chloride can also be used in the research of ischemia-reperfusion injury models[1][2][3][4].

IC50 & Target[3]

Caspase 3

 

Bcl-2

 

HO-1

 

In Vitro

Co(III) protoporphyrin IX chloride (0-25 μM; 2-16 hours) can upregulate the levels of HO-1 and Nrf2, and reduce the protein level of Bach1 in Huh-7 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Co(III) protoporphyrin IX chloride Related Antibodies

Western Blot Analysis[1]

Cell Line: Huh-7 cells
Concentration: 0, 0.5, 1, 5 and 10 μM
Incubation Time: 16 h
Result: Increased the levels of HO-1 and Nrf2 in a dose-dependent manner.
Inhibited the levels of Bach1 in a dose-dependent manner.
In Vivo

Co(III) protoporphyrin IX chloride (125 μmol/kg; subcutaneous injection; single dose) reduces hepatic cytochrome P450 levels in male rats, while inhibiting δ-aminolevulinate synthase activity and inducing heme oxygenase activity[2].
Co(III) protoporphyrin IX chloride (5 mg/kg; intraperitoneal injection; single dose) has an improving effect in a mouse model of hepatic ischemia-reperfusion injury[3].
Co(III) protoporphyrin IX chloride (5 mg/kg; intraperitoneal injection; 6 times over 11 days) exhibits antibacterial activity in mice infected with Yersinia pestis[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice (25-30 g) with liver ischemia-reperfusion (I/R) injury[3]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; single dose
Result: Significantly reduced the increase in serum levels of AST and ALT induced by I/R injury.
Alleviated hepatocellular swelling and histopathological damage.
Increased the protein expression levels of HO-1 and Bcl-2, decreased the expression of caspase 3, and reduced the percentage of apoptotic hepatocytes compared with the I/R group.
Animal Model: C57BL/6 mice treated Yersinia pestis CO92[4]
Dosage: 5 mg/kg
Administration: Intraperitoneal injection; 24 h prior to challenge and on the day of challenge, additional treatments were provided every other day for the duration of the 10-day observation period
Result: Improved survival, increased the time to mortality, reduced pulmonary bacterial burden, and increased HO-1 levels in the lungs compared to vehicle-treated mice.
Molecular Weight

655.03

Formula

C34H32ClCoN4O4
CAS No.
Appearance

Solid

Color

Brown to black

SMILES

O=C(CCC1=C(C)C2=[N]3C1=CC4=C(CCC(O)=O)C(C)=C5C=C6C(C=C)=C(C)C(C=C7C(C=C)=C(C)C8=C2)=[N]6[Co+3]3([N-]78)([N-]54)[Cl-])O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 62.5 mg/mL (95.42 mM; ultrasonic and warming and heat to 60°C; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5266 mL 7.6332 mL 15.2665 mL
5 mM 0.3053 mL 1.5266 mL 3.0533 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation

Purity: ≥95.0%

SDS (393 KB)

COA (263 KB) HNMR (285 KB) MS (71 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5266 mL 7.6332 mL 15.2665 mL 38.1662 mL
5 mM 0.3053 mL 1.5266 mL 3.0533 mL 7.6332 mL
10 mM 0.1527 mL 0.7633 mL 1.5266 mL 3.8166 mL
15 mM 0.1018 mL 0.5089 mL 1.0178 mL 2.5444 mL
20 mM 0.0763 mL 0.3817 mL 0.7633 mL 1.9083 mL
25 mM 0.0611 mL 0.3053 mL 0.6107 mL 1.5266 mL
30 mM 0.0509 mL 0.2544 mL 0.5089 mL 1.2722 mL
40 mM 0.0382 mL 0.1908 mL 0.3817 mL 0.9542 mL
50 mM 0.0305 mL 0.1527 mL 0.3053 mL 0.7633 mL
60 mM 0.0254 mL 0.1272 mL 0.2544 mL 0.6361 mL
80 mM 0.0191 mL 0.0954 mL 0.1908 mL 0.4771 mL
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Co(III) protoporphyrin IX chloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Co(III) protoporphyrin IX102601-60-5Protoporphyrin IX cobaltic CoPPIX-ClHeme Oxygenase (HO)ApoptosisBcl-2 FamilyCaspaseCytochrome P450BacterialKeap1-Nrf2Heme OxygenaseCYPsHuh-7 cellsischemia-reperfusion injury modelYersinia pestisInhibitorinhibitorinhibit

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