2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR MAPK/ERK Pathway Stem Cell/Wnt
  3. EGFR Akt ERK
  4. Lazertinib mesylate

Lazertinib mesylate  (Synonyms: YH25448 mesylate; GNS-1480 mesylate)

Cat. No.: HY-109061B
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Lazertinib (mesylate) (YH25448 (mesylate); GNS-1480 (mesylate)) is an orally active EGFR inhibitor that can penetrate the blood-brain barrier. Lazertinib (mesylate) inhibits p-EGFR, p-AKT and p-ERK signaling pathways, leading to apoptosis. Lazertinib (mesylate) has anti-tumor activity in the mouse H1975-luc BM xenograft model. Lazertinib (mesylate) can be used in the study of non-small cell lung cancer.

For research use only. We do not sell to patients.

Lazertinib mesylate Chemical Structure

Lazertinib mesylate Chemical Structure

CAS No. : 2247995-37-3

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Lazertinib mesylate Related Antibodies

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1 Publications Citing Use of MCE Lazertinib mesylate

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Description

Lazertinib (mesylate) (YH25448 (mesylate); GNS-1480 (mesylate)) is an orally active EGFR inhibitor that can penetrate the blood-brain barrier. Lazertinib (mesylate) inhibits p-EGFR, p-AKT and p-ERK signaling pathways, leading to apoptosis. Lazertinib (mesylate) has anti-tumor activity in the mouse H1975-luc BM xenograft model. Lazertinib (mesylate) can be used in the study of non-small cell lung cancer[1].

Molecular Weight

650.75

Formula

C31H38N8O6S
CAS No.
SMILES

O=C(NC1=CC(NC2=NC=CC(N3N=C(C(CN(C)C)=C3)C4=CC=CC=C4)=N2)=C(C=C1N5CCOCC5)OC)C=C.O=S(O)(C)=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
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Lazertinib mesylate Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lazertinib2247995-37-3YH25448GNS-1480YH 25448YH-25448GNS1480GNS 1480EGFRAktERKEpidermal growth factor receptorErbB-1HER1PKBProtein kinase BExtracellular signal regulated kinasesmouse H1975-luc BM xenograft modelPDXNSCLCBBBYU-1098YU-1153YU-1150YU-1092YU-1099and YU-1097 cell linesBa/F3 cellsInhibitorinhibitorinhibit

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