2. JAK/STAT Signaling Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR MAPK/ERK Pathway Stem Cell/Wnt
  3. EGFR Akt ERK
  4. Lazertinib mesylate

Lazertinib mesylate  (Synonyms: YH25448 mesylate; GNS-1480 mesylate)

Cat. No.: HY-109061B Purity: 99.85%
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Lazertinib (mesylate) (YH25448 (mesylate); GNS-1480 (mesylate)) is an orally active EGFR inhibitor that can penetrate the blood-brain barrier. Lazertinib (mesylate) inhibits p-EGFR, p-AKT and p-ERK signaling pathways, leading to apoptosis. Lazertinib (mesylate) has anti-tumor activity in the mouse H1975-luc BM xenograft model. Lazertinib (mesylate) can be used in the study of non-small cell lung cancer.

For research use only. We do not sell to patients.

Lazertinib mesylate Chemical Structure

Lazertinib mesylate Chemical Structure

CAS No. : 2247995-37-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Lazertinib mesylate:

Lazertinib mesylate Related Antibodies

Top Publications Citing Use of Products

1 Publications Citing Use of MCE Lazertinib mesylate

View All EGFR Isoform Specific Products:

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EGFR/ErbB1/HER1 ErbB2/HER2 ErbB3/HER3 ErbB4/HER4

View All Akt Isoform Specific Products:

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Akt Akt1 Akt2 Akt3

View All ERK Isoform Specific Products:

View All Isoforms
ERK ERK1 ERK2 ERK5 ERK8

  • Biological Activity

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  • Customer Review

Description

Lazertinib (mesylate) (YH25448 (mesylate); GNS-1480 (mesylate)) is an orally active EGFR inhibitor that can penetrate the blood-brain barrier. Lazertinib (mesylate) inhibits p-EGFR, p-AKT and p-ERK signaling pathways, leading to apoptosis. Lazertinib (mesylate) has anti-tumor activity in the mouse H1975-luc BM xenograft model. Lazertinib (mesylate) can be used in the study of non-small cell lung cancer[1].

Molecular Weight

650.75

Formula

C31H38N8O6S
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(NC1=CC(NC2=NC=CC(N3N=C(C(CN(C)C)=C3)C4=CC=CC=C4)=N2)=C(C=C1N5CCOCC5)OC)C=C.O=S(O)(C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (153.67 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.5367 mL 7.6834 mL 15.3669 mL
5 mM 0.3073 mL 1.5367 mL 3.0734 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Concentration
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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

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Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

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(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.5367 mL 7.6834 mL 15.3669 mL 38.4172 mL
5 mM 0.3073 mL 1.5367 mL 3.0734 mL 7.6834 mL
10 mM 0.1537 mL 0.7683 mL 1.5367 mL 3.8417 mL
15 mM 0.1024 mL 0.5122 mL 1.0245 mL 2.5611 mL
20 mM 0.0768 mL 0.3842 mL 0.7683 mL 1.9209 mL
25 mM 0.0615 mL 0.3073 mL 0.6147 mL 1.5367 mL
30 mM 0.0512 mL 0.2561 mL 0.5122 mL 1.2806 mL
40 mM 0.0384 mL 0.1921 mL 0.3842 mL 0.9604 mL
50 mM 0.0307 mL 0.1537 mL 0.3073 mL 0.7683 mL
60 mM 0.0256 mL 0.1281 mL 0.2561 mL 0.6403 mL
80 mM 0.0192 mL 0.0960 mL 0.1921 mL 0.4802 mL
100 mM 0.0154 mL 0.0768 mL 0.1537 mL 0.3842 mL
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Lazertinib mesylate Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Lazertinib2247995-37-3YH25448GNS-1480YH 25448YH-25448GNS1480GNS 1480EGFRAktERKEpidermal growth factor receptorErbB-1HER1PKBProtein kinase BExtracellular signal regulated kinasesmouse H1975-luc BM xenograft modelPDXNSCLCBBBYU-1098YU-1153YU-1150YU-1092YU-1099and YU-1097 cell linesBa/F3 cellsInhibitorinhibitorinhibit

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