2. Anti-infection Cell Cycle/DNA Damage
  3. Bacterial Antibiotic DNA/RNA Synthesis Topoisomerase
  4. Besifloxacin Hydrochloride

Besifloxacin Hydrochloride is a fourth generation fluoroquinolone antibiotic. Besifloxacin Hydrochloride is a DNA gyrase and topoisomerase IV inhibitor. Besifloxacin Hydrochloride has broad-spectrum antibacterial activity, it is effective against Gram-negative and Gram-positive aerobic and anaerobic strains and reduces the incidence of drug resistance. Besifloxacin Hydrochloride has anti-inflammatory activity. Besifloxacin Hydrochloride can be used in bacterial conjunctivitis research.

For research use only. We do not sell to patients.

Besifloxacin Hydrochloride

Besifloxacin Hydrochloride Chemical Structure

CAS No. : 405165-61-9

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Based on 1 publication(s) in Google Scholar

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Besifloxacin Hydrochloride Related Antibodies

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Description

Besifloxacin Hydrochloride is a fourth generation fluoroquinolone antibiotic. Besifloxacin Hydrochloride is a DNA gyrase and topoisomerase IV inhibitor. Besifloxacin Hydrochloride has broad-spectrum antibacterial activity, it is effective against Gram-negative and Gram-positive aerobic and anaerobic strains and reduces the incidence of drug resistance. Besifloxacin Hydrochloride has anti-inflammatory activity. Besifloxacin Hydrochloride can be used in bacterial conjunctivitis research[1][2][3][4].

IC50 & Target

Quinolone

 

In Vitro

Besifloxacin Hydrochloride (0.1-30 μg/mL, 18 h) inhibits the expression of IL-1α, G-CSF, IL-1ra, IL-6, GM-CSF, IL-12p40, IL-1β, IL-8, IP-10, MCP-1, and MIP-1α cytokines in THP-1 monocytes in a dose-dependent manner[1].
Besifloxacin Hydrochloride exhibits low cumulative minimum inhibitory concentration (MIC) values against S. aureus isolates, with only minimal increases in MIC observed as isolate resistance levels rise (0.015–8 μg/mL)[2].
Besifloxacin Hydrochloride shows only slight MIC elevation in response to increasing numbers of quinolone resistance-determining region (QRDR) mutations in DNA gyrase and topoisomerase IV of S. aureus isolates[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Besifloxacin Hydrochloride Related Antibodies
In Vivo

Besifloxacin Hydrochloride (6 mg/mL, Topical administration, 19 total doses over 8 h) reduces the clinical severity of methicillin-resistant Staphylococcus aureus (MRSA) infections in rabbits[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Rabbit MRSA infection model (New Zealand white rabbits, 2-3 kg and of either sex)[4]
Dosage: One drop (6 mg/mL) was placed on each eye
Administration: Topical administration, 19 total doses over 8 h
Result: Reduced corneal ulcers and edema in rabbit eyes.
Reduced colony-forming unit (CFU) recovered in the cornea.
Compared with gatifloxacin and moxifloxacin, the MIC was minimal (1 μg/mL).
Clinical Trial
Molecular Weight

430.30

Formula

C19H22Cl2FN3O3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4C[C@H](N)CCCC4)=C3Cl)C1=O)O.[H]Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

Ethanol : < 1 mg/mL (insoluble)

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Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Working solution concentration: mg/mL
Purity & Documentation
References
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Besifloxacin Hydrochloride Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Besifloxacin405165-61-9BacterialAntibioticDNA/RNA SynthesisTopoisomeraseAnti-bacterialTHP-1IL-1αG-CSFIL-1raIL-6GM-CSFIL-12p40IL-1βIL-8IP-10MCP-1and MIP-1αconjunctivitisRabbit MRSA infection modelInhibitorinhibitorinhibit

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