Besifloxacin Hydrochloride

Name: Besifloxacin Hydrochloride
Brand: MedChemExpress
SKU: HY-17028
Rating: 4.5 (1 reviews)

Cat. No.: HY-17028 Purity: 98.11%: Data Sheet
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Besifloxacin Hydrochloride is a fourth generation fluoroquinolone antibiotic. Besifloxacin Hydrochloride is a DNA gyrase and topoisomerase IV inhibitor. Besifloxacin Hydrochloride has broad-spectrum antibacterial activity, it is effective against Gram-negative and Gram-positive aerobic and anaerobic strains and reduces the incidence of drug resistance. Besifloxacin Hydrochloride has anti-inflammatory activity. Besifloxacin Hydrochloride can be used in bacterial conjunctivitis research.

For research use only. We do not sell to patients.

Besifloxacin Hydrochloride Chemical Structure

CAS No. : 405165-61-9

Size	Stock	Quantity
5 mg	In-stock	Estimated Time of Arrival: December 31
10 mg	In-stock	Estimated Time of Arrival: December 31
25 mg	In-stock	Estimated Time of Arrival: December 31
50 mg	In-stock	Estimated Time of Arrival: December 31
100 mg	In-stock	Estimated Time of Arrival: December 31
200 mg	Get quote
500 mg	Get quote

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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Besifloxacin Hydrochloride:

(Rac)-Besifloxacin hydrochloride Get quote
Besifloxacin Get quote
Besifloxacin Hydrochloride (Standard) Get quote

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Topoisomerase Topo I Topo II

Biological Activity
Purity & Documentation
References
Customer Review

Description

IC₅₀ & Target

Quinolone

In Vitro

Besifloxacin Hydrochloride (0.1-30 μg/mL, 18 h) inhibits the expression of IL-1α, G-CSF, IL-1ra, IL-6, GM-CSF, IL-12p40, IL-1β, IL-8, IP-10, MCP-1, and MIP-1α cytokines in THP-1 monocytes in a dose-dependent manner^[1].
Besifloxacin Hydrochloride exhibits low cumulative minimum inhibitory concentration (MIC) values against S. aureus isolates, with only minimal increases in MIC observed as isolate resistance levels rise (0.015–8 μg/mL)^[2].
Besifloxacin Hydrochloride shows only slight MIC elevation in response to increasing numbers of quinolone resistance-determining region (QRDR) mutations in DNA gyrase and topoisomerase IV of S. aureus isolates^[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

In Vivo

Besifloxacin Hydrochloride (6 mg/mL, Topical administration, 19 total doses over 8 h) reduces the clinical severity of methicillin-resistant Staphylococcus aureus (MRSA) infections in rabbits^[4].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model:	Rabbit MRSA infection model (New Zealand white rabbits, 2-3 kg and of either sex)^[4]
Dosage:	One drop (6 mg/mL) was placed on each eye
Administration:	Topical administration, 19 total doses over 8 h
Result:	Reduced corneal ulcers and edema in rabbit eyes. Reduced colony-forming unit (CFU) recovered in the cornea. Compared with gatifloxacin and moxifloxacin, the MIC was minimal (1 μg/mL).

Clinical Trial

Molecular Weight

430.30

Formula

C₁₉H₂₂Cl₂FN₃O₃

CAS No.

405165-61-9

Appearance

Solid

Color

White to off-white

SMILES

O=C(C1=CN(C2CC2)C3=C(C=C(F)C(N4C[C@H](N)CCCC4)=C3Cl)C1=O)O.[H]Cl

Shipping

Room temperature in continental US; may vary elsewhere.

Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility

In Vitro:

Ethanol : < 1 mg/mL (insoluble)

DMSO : < 1 mg/mL (insoluble or slightly soluble)

H₂O : < 0.1 mg/mL (insoluble)

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Concentration _(start) × Volume _(start) = Concentration _(final) × Volume _(final)

This equation is commonly abbreviated as: C₁V₁ = C₂V₂

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In Vivo Dissolution Calculator

Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.

Calculation results:

Working solution concentration: mg/mL

Purity & Documentation

Purity: 98.11%

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Data Sheet (286 KB) SDS (392 KB)

COA (251 KB) RP-HPLC (243 KB)

Handling Instructions (2659 KB)

References

[1]. Zhang JZ, et al. Besifloxacin, a novel fluoroquinolone antimicrobial agent, exhibits potent inhibition of pro-inflammatory cytokines in human THP-1 monocytes. J Antimicrob Chemother. 2008 Jan;61(1):111-6. [Content Brief]

[2]. Sanfilippo CM, et al. Topoisomerase mutations that are associated with high-level resistance to earlier fluoroquinolones in Staphylococcus aureus have less effect on the antibacterial activity of besifloxacin. Chemotherapy. 2011;57(5):363-71. [Content Brief]

[3]. Haas W, et al. Besifloxacin, a novel fluoroquinolone, has broad-spectrum in vitro activity against aerobic and anaerobic bacteria. Antimicrob Agents Chemother. 2009 Aug;53(8):3552-60. [Content Brief]

[4]. Sanders ME, et al. Efficacy of besifloxacin in an early treatment model of methicillin-resistant Staphylococcus aureus keratitis. J Ocul Pharmacol Ther. 2010 Apr;26(2):193-8. [Content Brief]