2. GPCR/G Protein Neuronal Signaling
  3. CGRP Receptor
  4. CGRP antagonist 7

CGRP antagonist 7 is a potent calcitonin gene-related peptide receptor (CGRP) antagonist with a Ki of 0.029 nM. CGRP antagonist 7 Inhibit the production of cyclic adenosine monophosphate (cAMP) with IC50 of 1.5 nM. CGRP antagonist 7 can be used for the study of migraine.

For research use only. We do not sell to patients.

CGRP antagonist 7 Chemical Structure

CGRP antagonist 7 Chemical Structure

CAS No. : 2173508-07-9

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CGRP antagonist 7 Related Antibodies

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Description

CGRP antagonist 7 is a potent calcitonin gene-related peptide receptor (CGRP) antagonist with a Ki of 0.029 nM. CGRP antagonist 7 Inhibit the production of cyclic adenosine monophosphate (cAMP) with IC50 of 1.5 nM. CGRP antagonist 7 can be used for the study of migraine[1].

In Vitro

CGRP antagonist 7 (Compound 15) (0.1-10 μM, 0-60 min) exhibits the IC50 more than 100 μM in human hepatocellular carcinoma (HepaRG) cells and moderate inhibition of CYP3A (IC50 = 6.6 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

CGRP antagonist 7 Related Antibodies
In Vivo

CGRP antagonist 7 (Compound 15) (1 mg/kg, i,p., single dose) significantly inhibits the increase in blood flow induced by CGRP in marmoset facial blood flow mode[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Marmoset facial blood flow mode induced by intravenous administration of hαCGRP at a dose of 10 μg/kg administered at −15, 15, 45, and 90 min[1]
Dosage: 1 mg/kg
Administration: Intraperitoneal injection (i.p.), single dose
Result: Significantly inhibited the increase in facial blood flow induced by CGRP (Emax = 84% at 45 min).
Molecular Weight

529.61

Formula

C30H32FN5O3
CAS No.
SMILES

CC1=NNC(C(CC2=CC=C(C=C2C)C(NCC(N3[C@@H](CC[C@@H]3C(C)(C#N)C)C4=CC(F)=CC=C4)=O)=O)=C1)=O
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Room temperature in continental US; may vary elsewhere.
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Purity & Documentation
References
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CGRP antagonist 7 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

CGRP antagonist 72173508-07-9CGRP antagonist7CGRP antagonist-7CGRP ReceptorCalcitonin gene-related peptide receptorFragment-BasedPrimate modelRatMigraineOral bioavailabilityInhibitorinhibitorinhibit

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CGRP antagonist 7
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