2. Protein Tyrosine Kinase/RTK MAPK/ERK Pathway Stem Cell/Wnt
  3. SHP2 FGFR p38 MAPK ERK
  4. LC-SF-14

LC-SF-14 is a selective dual inhibitor of SHP2 and FGFR (IC50 values are 71.6 and 8.9 nM, respectively). LC-SF-14 inhibits FGFR2-FRS2α-SHP2-MAPK signaling and ERK phosphorylation. LC-SF-14 inhibits the proliferation of KATOIII cancer cells (IC50: 9.2 nM). LC-SF-14 has antitumor activity in the SNU-16 xenograft mouse model. LC-SF-14 can be used in FGFR2-driven gastric cancer research.

For research use only. We do not sell to patients.

LC-SF-14 Chemical Structure

LC-SF-14 Chemical Structure

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LC-SF-14 Related Antibodies

Top Publications Citing Use of Products

View All p38 MAPK Isoform Specific Products:

View All Isoforms
p38 MAPK p38α p38β MAPK13 p38δ p38γ

View All ERK Isoform Specific Products:

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ERK ERK1 ERK2 ERK5 ERK8

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Description

LC-SF-14 is a selective dual inhibitor of SHP2 and FGFR (IC50 values are 71.6 and 8.9 nM, respectively). LC-SF-14 inhibits FGFR2-FRS2α-SHP2-MAPK signaling and ERK phosphorylation. LC-SF-14 inhibits the proliferation of KATOIII cancer cells (IC50: 9.2 nM). LC-SF-14 has antitumor activity in the SNU-16 xenograft mouse model. LC-SF-14 can be used in FGFR2-driven gastric cancer research[1].

Molecular Weight

979.38

Formula

C44H50Cl3N13O5S
SMILES

O=C(NC1=CC=CC(SC2=NC=C(N3CCC(C)(N)CC3)N=C2N)=C1Cl)CCC(N4CCN(C5=CC=C(NC6=NC=NC(N(C)C(NC7=C(Cl)C(OC)=CC(OC)=C7Cl)=O)=C6)C=C5)CC4)=O
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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LC-SF-14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

LC-SF-14SHP2FGFRp38 MAPKERKSrc homology phosphatase 2PTPN11Fibroblast growth factor receptorExtracellular signal regulated kinasesGastric cancerKATO III cellsSNU16 cellsSNU-16 xenograft mouse modelInhibitorinhibitorinhibit

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