2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. ING-1

ING-1 (heMab) is a high-affinity humanized monoclonal antibody against epithelial cell adhesion molecule (Ep-CAM). ING-1 is a transmembrane glycoprotein mediating Ca2+. ING-1 binds to Ep-CAM on tumor cells and exhibits potent in vitro activity, targeting and inhibiting tumor growth and metastasis in mouse cancer models. ING-1 is useful in the research of breast, colorectal, and lung cancers, among other cancers.

For research use only. We do not sell to patients.

ING-1

ING-1 Chemical Structure

Size Stock
1 mg   Get quote  
5 mg   Get quote  
10 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

ING-1 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ING-1 (heMab) is a high-affinity humanized monoclonal antibody against epithelial cell adhesion molecule (Ep-CAM). ING-1 is a transmembrane glycoprotein mediating Ca2+. ING-1 binds to Ep-CAM on tumor cells and exhibits potent in vitro activity, targeting and inhibiting tumor growth and metastasis in mouse cancer models. ING-1 is useful in the research of breast, colorectal, and lung cancers, among other cancers[1][2].

Isotype

Human IgG1 kappa
Recommend Isotype Controls
Species Reactivity

Human
IC50 & Target

EpCAM/TROP1/CD326
In Vitro

ING-1(0.1-10000 nM, 4℃ for 5 h) competes similarly with radiolabeled chimeric ING-1 for binding to Ep-CAM in HT -29 human cells, with an Kd of 2 to 5 nM[1].
ING-1(37℃ for 4 h) caused a concentration-dependent lysis of 51Cr-labeled BT-20, MCF-7, HT-29, CACO-2, NCI-H1568, PC-3, HPAF-II cells in ADCC and CDC activity assay[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ING-1 Related Antibodies
In Vivo

ING-1 (0.1-1.0 mg/kg, i.v., two doses per week, 3 weeks) reduces tumor size and metastases in HT-29 and PC-3 xenograft nude mice model[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: HT-29 xenograft (3x106/1.5x107) nude mice (20-25 g) model[1][2]
Dosage: 0.1, 0.3, or 1 mg/kg
Administration: i.v., one/two doses per week, 3 weeks
Result: Resulted in a dose-dependent reduction in tumor size relative to control, resulted in a 64% reduction in tumor size at the end of the experiment at 1 mg/kg.
Eliminated visible tumor nodules in body cavities of some animals, reduced tumor metastases on lung surfaces, resulted in 86% reduction of the average number of metastases at 1 mg/kg.
Inhibited micrometastases formation in Lung Tissues, reduced the average number of micrometastasis foci by 91% at 1 mg/kg.
Animal Model: PC-3 xenograft (5x106) nude mice (20-25 g) model[1]
Dosage: 0.1, 0.3, or 1 mg/kg
Administration: i.v., two doses per week, 3 weeks
Result: Resulted in a dose-dependent reduction in tumor size relative to control, resulted in a 71% reduction in tumor size at the end of the experiment at 1 mg/kg.
Gene ID

4072  [NCBI]

Accession
Target

EpCAM/TROP1/CD326
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
SMILES

N/A
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

ING-1 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ING-1heMabING1ING 1Transmembrane Glycoproteinmonoclonal antibodybreast cancerlung cancercolorectal cancerBT-20 cellsMCF-7 cellsHT-29 cellsCACO-2 cellsNCI-H1568 cellsPC-3 cellsHPAF-II cellsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ING-1
Cat. No.:
HY-P991646
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.