2. Apoptosis
  3. Apoptosis
  4. SP94

SP94 is a peptide ligand with high specificity for hepatocellular carcinoma cells. SP94 selectively binds to multiple hepatocellular carcinoma cell lines in vitro. SP94 inhibits tumor growth in a mouse model of hepatocellular carcinoma by promoting apoptosis and reducing angiogenesis. SP94 can be used as a specific probe for hepatocellular carcinoma imaging. SP94 is useful for hepatocellular carcinoma research.

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SP94

SP94 Chemical Structure

CAS No. : 1158983-49-3

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Description

SP94 is a peptide ligand with high specificity for hepatocellular carcinoma cells. SP94 selectively binds to multiple hepatocellular carcinoma cell lines in vitro. SP94 inhibits tumor growth in a mouse model of hepatocellular carcinoma by promoting apoptosis and reducing angiogenesis. SP94 can be used as a specific probe for hepatocellular carcinoma imaging. SP94 is useful for hepatocellular carcinoma research[1][2][3].

In Vitro

SP94 (40 nM of HspG41C-SM(PEG)n-SP94, 12/23 peptides/cage, 24 h) could bind selectively to HepG2 and Huh-7 cells, but does not bind to HeLa and RLN-8 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SP94 Related Antibodies

Immunofluorescence[2]

Cell Line: HepG2 and Huh-7 cells
Concentration: 40 nM of HspG41C-SM(PEG)n-SP94, 12/23 peptides/cage
Incubation Time: 24 h
Result: Induced Alexa488 green fluorescence, increased the binding of conjugates with increasing SP94 peptide numbers on liposomes.
In Vivo

SP94 (100 µg + PC94, once/1 mg/kg (SP94-LD), i.v., once-twice a week, for 2-4 consecutive weeks) inhibits recovery of phage particle from tumor tissue, inhibits tumor growth through enhances tumor apoptosis and decreases tumor angiogenesis in Mahlavu cells xenograft mice model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Mahlavu cells (5x106) xenograft severe combined immunodeficient mice (4-6 weeks old) model[1]
Dosage: 100 µg + PC94
Administration: once
Result: Inhibited recovery of phage particle from tumor tissue, inhibited 88% of PC94 binding to tumor tissue.
Animal Model: Mahlavu cells (5x106) xenograft severe combined immunodeficient mice (4-6 weeks old) model[1]
Dosage: 1 mg/kg, with PEGylated liposomal Doxorubicin (HY-15142A) (SP94-LD).
Administration: i.v., twice a week, for 4 consecutive weeks
Result: Reduced the tumor size and weight, with 40% inhibition compared with that in the CP-LD- and LD-treated groups.
Increased the total WBC count, did not change body weight.
Showed marked disseminated necrotic/apoptotic areas, increased apoptotic tumor cells, decreased the density of blood vessels.
Animal Model: Mahlavu cells (5x106) xenograft severe combined immunodeficient mice (4-6 weeks old) model[1]
Dosage: 5 mg/kg, with PEGylated liposomal Doxorubicin (SP94-LD).
Administration: i.v., once a week, for 2 consecutive weeks
Result: Reduced the tumor size and weight, increased the total WBC count, showed marked disseminated necrotic/apoptotic areas, areas of CD31+ endothelial cells, decreased areas of CD31+ endothelial cells.
Molecular Weight

1337.61

Formula

C65H104N14O16
CAS No.
Sequence

Ser-Phe-Ser-Ile-Ile-His-Thr-Pro-Ile-Leu-Pro-Leu
Sequence Shortening

SFSIIHTPILPL
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References
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SP94 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SP941158983-49-3SP 94SP-94Apoptosispeptide ligandhepatocellular carcinomaHepG2 cellsHuh-7 cellsMahlavu cellssevere combined immunodeficient miceInhibitorinhibitorinhibit

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