2. Protein Tyrosine Kinase/RTK
  3. FGFR
  4. FGFR4-IN-14

FGFR4-IN-14 (Compound 27i) is a FGFR4 inhibitor (IC50: 2.4 nM. FGFR4-IN-14 inhibits the proliferation of V550L and N535K mutant strains, with IC50s of 21 nM, 2.5 nM, 171 nM against huh7, BaF3/ETV6-FGFR4-V550L and BaF3/ETV6-FGFR4-N535K cells respectively. FGFR4-IN-14 has potent antitumor efficacy in the Huh7 xenograft model. FGFR4-IN-14 can be used for research of hepatocellular carcinoma (HCC).

For research use only. We do not sell to patients.

FGFR4-IN-14

FGFR4-IN-14 Chemical Structure

CAS No. : 3027827-02-4

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FGFR4-IN-14 Related Antibodies

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Description

FGFR4-IN-14 (Compound 27i) is a FGFR4 inhibitor (IC50: 2.4 nM. FGFR4-IN-14 inhibits the proliferation of V550L and N535K mutant strains, with IC50s of 21 nM, 2.5 nM, 171 nM against huh7, BaF3/ETV6-FGFR4-V550L and BaF3/ETV6-FGFR4-N535K cells respectively. FGFR4-IN-14 has potent antitumor efficacy in the Huh7 xenograft model. FGFR4-IN-14 can be used for research of hepatocellular carcinoma (HCC)[1].

Cellular Effect
Cell Line Type Value Description References
BaF3 IC50
0.002 μM
Compound: 27i
Antiproliferative activity against mouse BaF3 cells harbouring ETV6-FGFR4-V550L mutant measured after 24 to 48 hrs by MTT assay
Antiproliferative activity against mouse BaF3 cells harbouring ETV6-FGFR4-V550L mutant measured after 24 to 48 hrs by MTT assay
[PMID: 37437349]
BaF3 IC50
0.172 μM
Compound: 27i
Antiproliferative activity against mouse BaF3 cells harbouring ETV6-FGFR4-N535K mutant measured after 24 to 48 hrs by MTT assay
Antiproliferative activity against mouse BaF3 cells harbouring ETV6-FGFR4-N535K mutant measured after 24 to 48 hrs by MTT assay
[PMID: 37437349]
Hep 3B2 IC50
0.038 μM
Compound: 27i
Antiproliferative activity against human Hep3B cells measured after 24 to 48 hrs by MTT assay
Antiproliferative activity against human Hep3B cells measured after 24 to 48 hrs by MTT assay
[PMID: 37437349]
HepG2 IC50
> 5 μM
Compound: 27i
Antiproliferative activity against human HepG2 cells measured after 24 to 48 hrs by MTT assay
Antiproliferative activity against human HepG2 cells measured after 24 to 48 hrs by MTT assay
[PMID: 37437349]
Huh-7 IC50
21 nM
Compound: 27i
Antiproliferative activity against human Huh-7 cells measured after 24 to 48 hrs by MTT assay
Antiproliferative activity against human Huh-7 cells measured after 24 to 48 hrs by MTT assay
[PMID: 37437349]
L02 IC50
> 10 μM
Compound: 27i
Antiproliferative activity against human L02 cells measured after 24 to 48 hrs by MTT assay
Antiproliferative activity against human L02 cells measured after 24 to 48 hrs by MTT assay
[PMID: 37437349]
Molecular Weight

522.43

Formula

C27H25Cl2N5O2
CAS No.
SMILES

C=CC(NC1=CC2=C(C=C1C3=NNC4=C3C=C(O[C@@H](C5=C(Cl)C=NC=C5Cl)C)C=C4)CCN(C)C2)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FGFR4-IN-14 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR4-IN-143027827-02-4FGFRFibroblast growth factor receptorHuh7 xenograftantitumorV550LN535K mutantHCCliver cancerInhibitorinhibitorinhibit

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