2. Anti-infection
  3. Virus Protease
  4. SGC-NSP2hel-1

SGC-NSP2hel-1 is a potent, specific and orally active inhibitor of the nsP2 helicase with a CC50 > 250 µM and Selectivity Index of > 4000. SGC-NSP2hel-1 has broad spectrum activity against multiple alphaviruses. SGC-NSP2hel-1 reduces virus replication and limited virus-induced pathology by forming a stable complex with nsP2 and ATP in a preclinical small animal model of CHIKV disease[1].

For research use only. We do not sell to patients.

SGC-NSP2hel-1 Chemical Structure

SGC-NSP2hel-1 Chemical Structure

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SGC-NSP2hel-1 Related Antibodies

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Description

SGC-NSP2hel-1 is a potent, specific and orally active inhibitor of the nsP2 helicase with a CC50 > 250 µM and Selectivity Index of > 4000. SGC-NSP2hel-1 has broad spectrum activity against multiple alphaviruses. SGC-NSP2hel-1 reduces virus replication and limited virus-induced pathology by forming a stable complex with nsP2 and ATP in a preclinical small animal model of CHIKV disease[1].

In Vitro

SGC-NSP2hel-1 (8-point 4 fold dose, daily for 3 days) inhibits multiple alphaviruses with very little impact on cell viability with a CC50 > 250 µM and Selectivity Index of > 4000 in MRC-5 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

SGC-NSP2hel-1 Related Antibodies
In Vivo

SGC-NSP2hel-1 (30 mg/kg, p.o., bid) reduces viral replication and disease in a preclinical model of CHIKV infection[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: CHIKV models of 6-week mice[1]
Dosage: 30 mg/kg
Administration: Orally twice daily and once daily with 100mg/kg 1-ABT, beginning at 12 h prior to infection with CHIKV.
Result: Significantly reduced footpad swelling and virus replication in the ipsilateral foot and serum.
Significantly decreased virus-induced pathology, with decreased inflammatory cell recruitment and reduced myositis and muscle damage.
Showed no apparent toxicity (body weight and H&E staining).
Molecular Weight

474.66

Synonyms

RA-0188293

Formula

C26H38N2O4S
SMILES

O=C(C1(CCCC1)C2=CC=CC=C2)N(CC3)CCC43OCC[C@@H](CN5CCCCS5(=O)=O)C4
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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SGC-NSP2hel-1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

SGC-NSP2hel-1RA-0188293RA0188293RA 0188293Virus ProteaseAlphavirusesCHIKVNon-structural protein 2 (nsP2)Inhibitorinhibitorinhibit

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