6-Thio-GTP tetrasodium (Synonyms: 6-Thioguanosine-5'-triphosphate tetrasodium)

Cat. No.: HY-131598C: Data Sheet Handling Instructions
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6-Thio-GTP (tetrasodium) is a Vav1-Rac inhibitor. 6-Thio-GTP (tetrasodium) inhibits TCR-stimulated T cell proliferation and CD28-mediated T cell survival. 6-Thio-GTP (tetrasodium) has an immunosuppressive effect in a mouse cardiac allograft transplant model and prolongs cardiac allograft survival.

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6-Thio-GTP tetrasodium Chemical Structure

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Description	6-Thio-GTP (tetrasodium) is a Vav1-Rac inhibitor. 6-Thio-GTP (tetrasodium) inhibits TCR-stimulated T cell proliferation and CD28-mediated T cell survival. 6-Thio-GTP (tetrasodium) has an immunosuppressive effect in a mouse cardiac allograft transplant model and prolongs cardiac allograft survival^[1].
Molecular Weight	627.17
Formula	C₁₀H₁₂N₅Na₄O₁₃P₃S
SMILES	O[C@H]1[C@@H](O)[C@H](N2C=NC3=C2NC(N)=NC3=S)O[C@@H]1COP(OP(OP(O[Na])(O[Na])=O)(O[Na])=O)(O[Na])=O
Shipping	Room temperature in continental US; may vary elsewhere.
Storage	Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation	Data Sheet (269 KB) Handling Instructions (2659 KB)
References	[1]. Wang S, et al. Enhanced cardiac allograft survival by Vav1-Rac signaling blockade in a mouse model. Transpl Immunol. 2007 Jul;18(1):53-61. [Content Brief]

6-Thio-GTP tetrasodium Related Classifications

Inflammation/Immunology

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Help & FAQs

Do most proteins show cross-species activity?
Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

6-Thio-GTP tetrasodium6-Thioguanosine-5'-triphosphate tetrasodiumRasT cellsCD28TCRmouse cardiac allograft transplant modelCD4+CD25+CD4+Foxp3+Inhibitorinhibitorinhibit

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6-Thio-GTP tetrasodium (Synonyms: 6-Thioguanosine-5'-triphosphate tetrasodium)

Other Forms of 6-Thio-GTP tetrasodium:

6-Thio-GTP tetrasodium Related Antibodies

Featured Recommendations

•Related Small Molecules:

•Related Proteins:

View All Ras Isoform Specific Products:

Biological Activity

Purity & Documentation

References

Customer Review

6-Thio-GTP tetrasodium Related Classifications

Molarity Calculator

Dilution Calculator