2. Metabolic Enzyme/Protease NF-κB Immunology/Inflammation
  3. MMP Lipoxygenase Reactive Oxygen Species (ROS)
  4. 10-Butyl Ether Minocycline

10-Butyl Ether Minocycline, a Minocycline (HY-17412A) derivative, is an MMP-8 and MMP-9 inhibitor with IC50s of 69.4 µM and 47.0 µM, respectively. 10-Butyl Ether Minocycline shows a nearly complete loss of antimicrobial activity against E. coli, S. typhi, and C. albicans. 10-Butyl Ether Minocycline suppresses LPS (HY-D1056)-induced microglial activation. 10-Butyl Ether Minocycline inhibits VEGF-induced endothelial cell migration and L-Glutamine (HY-N0390)-induced ROS levels. 10-Butyl Ether Minocycline significantly reduces alcohol consumption in the Chronic Intermittent Ethanol (CIE) mouse model of alcohol dependence. 10-Butyl Ether Minocycline can be used for the study of neuroimmune-inflammatory diseases and Alcohol use disorder (AUD).

For research use only. We do not sell to patients.

10-Butyl Ether Minocycline

10-Butyl Ether Minocycline Chemical Structure

CAS No. : 488815-65-2

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

10-Butyl Ether Minocycline Related Antibodies

Top Publications Citing Use of Products

View All MMP Isoform Specific Products:

View All Isoforms
MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

View All Lipoxygenase Isoform Specific Products:

View All Isoforms
5-LOX 12-LOX 15-LOX

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

10-Butyl Ether Minocycline, a Minocycline (HY-17412A) derivative, is an MMP-8 and MMP-9 inhibitor with IC50s of 69.4 µM and 47.0 µM, respectively. 10-Butyl Ether Minocycline shows a nearly complete loss of antimicrobial activity against E. coli, S. typhi, and C. albicans. 10-Butyl Ether Minocycline suppresses LPS (HY-D1056)-induced microglial activation. 10-Butyl Ether Minocycline inhibits VEGF-induced endothelial cell migration and L-Glutamine (HY-N0390)-induced ROS levels. 10-Butyl Ether Minocycline significantly reduces alcohol consumption in the Chronic Intermittent Ethanol (CIE) mouse model of alcohol dependence. 10-Butyl Ether Minocycline can be used for the study of neuroimmune-inflammatory diseases and Alcohol use disorder (AUD)[1].

In Vitro

10-Butyl Ether Minocycline (1.56-100 µg/mL) shows a nearly complete loss of antimicrobial activity against E. coli, S. typhi, and C. albicans[1].
10-Butyl Ether Minocycline (0.1-500 µM, 24 h) demonstrates a dose-dependent reduction in NB cell viability with an IC50 of 102.1 µM[1].
10-Butyl Ether Minocycline (25 µM, 12 h) suppresses LPS (HY-D1056)-mediated microglial activation in N9 microglial cells[1].
10-Butyl Ether Minocycline (100 µM, 12 h) inhibits VEGF-induced endothelial cell migration in HUVECs[1].
10-Butyl Ether Minocycline (30-120 µM) attenuates L-Glutamine (HY-N0390)-induced ROS production dose-dependently in N9 microglial cells[1].
10-Butyl Ether Minocycline (30-120 µM) inhibits 15-LOX with IC50s of 92.6 µM[1].
10-Butyl Ether Minocycline (30-120 µM) does not exhibit significant mitochondrial toxicity compared to sodium azide in Human Colorectal Tumor (HCT) 116 cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

10-Butyl Ether Minocycline Related Antibodies

Western Blot Analysis[1]

Cell Line: N9 microglial cells
Concentration: 25 µM
Incubation Time: 12 h
Result: Reduced Iba1 expression in LPS-activated N9 microglial cells.
In Vivo

10-Butyl Ether Minocycline (60 mg/kg, i.p., single dose) significantly reduces alcohol consumption in the Chronic Intermittent Ethanol (CIE) mouse model of alcohol dependence[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Chronic Intermittent Ethanol (CIE) C57BL/6J mice (8 weeks)[1]
Dosage: 60 mg/kg
Administration: i.p. 2 hours before voluntary ethanol consumption
Result: Showed a significant reduction in alcohol consumption.
Molecular Weight

513.58

Formula

C27H35N3O7
CAS No.
SMILES

[H][C@@]12C[C@@]3(CC4=C(C=CC(OCCCC)=C4C(C3=C([C@@]1(C(C(C(N)=O)=C([C@H]2N(C)C)O)=O)O)O)=O)N(C)C)[H]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

10-Butyl Ether Minocycline Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

10-Butyl Ether Minocycline488815-65-2BEMMMPLipoxygenaseReactive Oxygen Species (ROS)Matrix metalloproteinasesLOXMMP-8/9NB cellsN9 microglial cellsneuroimmune-inflammatoryInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
10-Butyl Ether Minocycline
Cat. No.:
HY-175275
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.