2. Vitamin D Related/Nuclear Receptor
  3. Androgen Receptor
  4. AR antagonist 12

AR antagonist 12 (compound 20i) is an orally active androgen receptor antagonist wiith IC50 values of 119.3 μM and 98.2 μM for wt-AR and AR-F877L,respectively. AR antagonist 12 induces a dose-dependent and time-dependent reduction in AR, AR-V7, and PSA protein levels. AR antagonist 1 shows anticancer activuty and can be used for the study of Enzalutamide (HY-70002)-resistant Prostate cancer.

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AR antagonist 12 Chemical Structure

AR antagonist 12 Chemical Structure

CAS No. : 2902679-42-7

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AR antagonist 12 Related Antibodies

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Description

AR antagonist 12 (compound 20i) is an orally active androgen receptor antagonist wiith IC50 values of 119.3 μM and 98.2 μM for wt-AR and AR-F877L,respectively. AR antagonist 12 induces a dose-dependent and time-dependent reduction in AR, AR-V7, and PSA protein levels. AR antagonist 1 shows anticancer activuty and can be used for the study of Enzalutamide (HY-70002)-resistant Prostate cancer[1].

Molecular Weight

484.47

Formula

C24H23F3N6O2
CAS No.
SMILES

O=C(NC1=CN=C(C(C(F)(F)F)=C1)C#N)[C@@](O)(CN2CC3CCC(N3C4=CC=C(C=C4)C#N)C2)C
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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AR antagonist 12 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

AR antagonist 122902679-42-7AR antagonist12AR antagonist-12Androgen Receptor22Rv1 xenograft mouse modelC4-2BLNCaPInhibitorinhibitorinhibit

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