Guanosine 5'-O-(2-thiodiphosphate) trisodium  (Synonyms: GDPβS trisodium)

Guanosine 5'-O-(2-thiodiphosphate) (trisodium) (GDPβS (trisodium)) is a non-hydrolyzable derivative of GDP. Guanosine 5'-O-(2-thiodiphosphate) (trisodium) is an inhibitor of adenylyl caclase (AC) (K_i = 600 nM). Guanosine 5'-O-(2-thiodiphosphate) (trisodium) partially activates AC in the absence of GPT in cerebral cortex membranes of rodent models (EC₅₀ = 400 nM). Guanosine 5'-O-(2-thiodiphosphate) (trisodium) prevents the release of norepinephrine-induced nitric oxide in cardiac ventricular myocytes^[1][2][3].

525.21

C₁₀H₁₂N₅Na₃O₁₀P₂S

NC1=NC(C2=C(N1)N(C=N2)[C@@H]3O[C@H](COP(OP(O[Na])(S[Na])=O)(O[Na])=O)[C@@H](O)[C@H]3O)=O

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Svoboda, M., et al., (1980). Guanosine 5'-O-(2-thiodiphosphate) as a competitive inhibitor of GTP in hormone or cholera toxin-stimulated pancreatic adenylate cyclase. FEBS letters, 109(2), 275–279.  [Content Brief]

  [2]. Rasenick, M. M., et al., (1989). Guanosine-5'-O-thiodiphosphate functions as a partial agonist for the receptor-independent stimulation of neural adenylate cyclase. Brain research, 488(1-2), 105–113.  [Content Brief]

  [3]. Kanai, A. J., (1997). Beta-adrenergic regulation of constitutive nitric oxide synthase in cardiac myocytes. The American journal of physiology, 273(4), C1371–C1377.  [Content Brief]