ALG-001075 

ALG-001075, a capsid assembly modulator (CAM), is an orally active HBV inhibitor. ALG-001075 effectively blocks not only HBV DNA production but also extracellular HBsAg/HBeAg and intracellular HBV RNA in primary human hepatocytes. ALG-001075 shows pronounced reductions of circulating HBV DNA in the AAV-HBV mouse model. ALG-001075 can be used for the study of Chronic hepatitis B (CHB)^[1].

ALG-001075 (Compound 10) (0.01-1000 nM) inhibits HBV DNA production in HepG2.117cells with an EC₅₀ of 0.63 nM and an EC₉₀ of 3.17 nM^[1].
ALG-001075 (0.01-1000 nM) effectively blocks not only HBV DNA production (EC50 = 1.98 nM) but also extracellular HBsAg (EC₅₀ = 70 nM), HBeAg (EC₅₀ = 10.5 nM) and intracellular HBV RNA (EC₅₀ = 54.7 nM) in primary human hepatocytes^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ALG-001075 (Compound 10) (15-50 mg/kg, p.o., twice daily, 56 days ) shows pronounced reductions of circulating HBV DNA in the AAV-HBV mouse model^[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

422.41

C₂₂H₁₉FN₄O₄

2495324-66-6

N#CC1=CC(NC(C2=C(C)C(C(C(NC3(COC3)C#C)=O)=O)=C(C)N2C)=O)=CC=C1F

Room temperature in continental US; may vary elsewhere.

Please store the product under the recommended conditions in the Certificate of Analysis.

• [1]. Vendeville S, et al. The Discovery and Preclinical Profile of ALG-000184, a Prodrug of the Potent Hepatitis B Virus Capsid Assembly Modulator ALG-001075. J Med Chem. 2024 Dec 12;67(23):21126-21142.  [Content Brief]