2. Anti-infection
  3. HBV
  4. ALG-001075

ALG-001075, a capsid assembly modulator (CAM), is an orally active HBV inhibitor. ALG-001075 effectively blocks not only HBV DNA production but also extracellular HBsAg/HBeAg and intracellular HBV RNA in primary human hepatocytes. ALG-001075 shows pronounced reductions of circulating HBV DNA in the AAV-HBV mouse model. ALG-001075 can be used for the study of Chronic hepatitis B (CHB).

For research use only. We do not sell to patients.

ALG-001075

ALG-001075 Chemical Structure

CAS No. : 2495324-66-6

Size Price Stock Quantity
5 mg In-stock
10 mg In-stock
25 mg In-stock
50 mg In-stock
100 mg In-stock
200 mg   Get quote  
500 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

ALG-001075 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

ALG-001075, a capsid assembly modulator (CAM), is an orally active HBV inhibitor. ALG-001075 effectively blocks not only HBV DNA production but also extracellular HBsAg/HBeAg and intracellular HBV RNA in primary human hepatocytes. ALG-001075 shows pronounced reductions of circulating HBV DNA in the AAV-HBV mouse model. ALG-001075 can be used for the study of Chronic hepatitis B (CHB)[1].

In Vitro

ALG-001075 (Compound 10) (0.01-1000 nM) inhibits HBV DNA production in HepG2.117cells with an EC50 of 0.63 nM and an EC90 of 3.17 nM[1].
ALG-001075 (0.01-1000 nM) effectively blocks not only HBV DNA production (EC50 = 1.98 nM) but also extracellular HBsAg (EC50 = 70 nM), HBeAg (EC50 = 10.5 nM) and intracellular HBV RNA (EC50 = 54.7 nM) in primary human hepatocytes[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ALG-001075 Related Antibodies
In Vivo

ALG-001075 (Compound 10) (15-50 mg/kg, p.o., twice daily, 56 days ) shows pronounced reductions of circulating HBV DNA in the AAV-HBV mouse model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Male 5-6 weeks old C57BL/6 mice adeno-associated virus (AAV) HBV[1]
Dosage: 15, 50 mg/kg
Administration: p.o. twice daily for 56 days
Result: Showed pronounced reductions of circulating HBV DNA in the AAV-HBV mouse model.
Molecular Weight

422.41

Formula

C22H19FN4O4
CAS No.
Appearance

Solid

SMILES

N#CC1=CC(NC(C2=C(C)C(C(C(NC3(COC3)C#C)=O)=O)=C(C)N2C)=O)=CC=C1F
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 70 mg/mL (165.72 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3674 mL 11.8368 mL 23.6737 mL
5 mM 0.4735 mL 2.3674 mL 4.7347 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3674 mL 11.8368 mL 23.6737 mL 59.1842 mL
5 mM 0.4735 mL 2.3674 mL 4.7347 mL 11.8368 mL
10 mM 0.2367 mL 1.1837 mL 2.3674 mL 5.9184 mL
15 mM 0.1578 mL 0.7891 mL 1.5782 mL 3.9456 mL
20 mM 0.1184 mL 0.5918 mL 1.1837 mL 2.9592 mL
25 mM 0.0947 mL 0.4735 mL 0.9469 mL 2.3674 mL
30 mM 0.0789 mL 0.3946 mL 0.7891 mL 1.9728 mL
40 mM 0.0592 mL 0.2959 mL 0.5918 mL 1.4796 mL
50 mM 0.0473 mL 0.2367 mL 0.4735 mL 1.1837 mL
60 mM 0.0395 mL 0.1973 mL 0.3946 mL 0.9864 mL
80 mM 0.0296 mL 0.1480 mL 0.2959 mL 0.7398 mL
100 mM 0.0237 mL 0.1184 mL 0.2367 mL 0.5918 mL
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

ALG-001075 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ALG-0010752495324-66-6ALG001075ALG 001075HBVHepatitis B virusChronic hepatitis BHepG2.117cellsprimary human hepatocytesInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
ALG-001075
Cat. No.:
HY-177022
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.