2. Anti-infection Vitamin D Related/Nuclear Receptor Metabolic Enzyme/Protease Cell Cycle/DNA Damage GPCR/G Protein PI3K/Akt/mTOR
  3. Antibiotic Bacterial PPAR Prostaglandin Receptor PTEN Akt mTOR
  4. Cefminox sodium

Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits antibacterial activity. Cefminox sodium is a broad-spectrum, bactericidal cephalosporin antibiotic. Cefminox sodium also acts as a dual agonist of prostacyclin receptor (IP) and PPARγ. Cefminox sodium upregulates cAMP production and PTEN expression and inhibits Akt/mTOR signaling. Cefminox sodium also prevents pulmonary arterial hypertension in rat model.

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Cefminox sodium Chemical Structure

Cefminox sodium Chemical Structure

CAS No. : 75498-96-3

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Based on 1 publication(s) in Google Scholar

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Cefminox sodium Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

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Description

Cefminox sodium (MT-141) is a semisynthetic cephamycin, which exhibits antibacterial activity. Cefminox sodium is a broad-spectrum, bactericidal cephalosporin antibiotic. Cefminox sodium also acts as a dual agonist of prostacyclin receptor (IP) and PPARγ. Cefminox sodium upregulates cAMP production and PTEN expression and inhibits Akt/mTOR signaling. Cefminox sodium also prevents pulmonary arterial hypertension in rat model[1][2].

IC50 & Target[1][2]

PPARγ

 

IP Receptor

 

Bacterial

 

In Vitro

Cefminox sodium (Compound MT-141) (0.1-800 μg/mL) is more active against gram-negative and anaerobic bacteria than against gram-positive bacteria[1].
Cefminox sodium (10-50 μM, 48 h) significantly inhibits the hypoxia-induced cell proliferation dose-dependently in primary pulmonary artery smooth muscle cells (PASMCs) through the enhancement of both IP and PPARγ activities[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cefminox sodium Related Antibodies

Western Blot Analysis[2]

Cell Line: Primary pulmonary artery smooth muscle cells (PASMCs)
Concentration: 10 and 50 μM
Incubation Time: 48 h
Result: Increased PTEN mRNA levels.
Increased PTEN protein levels in both normoxic and hypoxic conditions.
Inhibited the Akt/mTOR signaling pathway through elevation of PTEN protein levels.
Inhibited cell growth by up-regulation PTEN expression and inhibiting Akt/mTOR signaling in PASMCs under hypoxic conditions.
In Vivo

Cefminox sodium (Compound MT-141) (2-480 mg/kg, s.c., single dose) shows the highest efficacy against strains of Escherichia coli, Klebsiella pneumoniae, Salmonella enteritidis, Proteus morganii, Proteus rettgeri, Proteus vulgaris, Yersinia enterocolitica, Psudomonas cepacia, and Clostridium perfringens in female Slc:ddY mice model[1].
Cefminox sodium (1-1000 mg/kg, s.c., single dose) gives dose-related serum levels in male Slc:ddY mice[1].
Cefminox sodium (160-320 mg/kg/day, i.v., single dose) significantly decreases mean pulmonary artery pressure (mPAP) in male SD rats with hypoxia-induced pulmonary hypertension (HPH)[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Sprague Dawley (SD) rats (150-200 g) with hypoxia-induced pulmonary hypertension (HPH)[2]
Dosage: 160 and 320 mg/kg/day
Administration: Intravenous injection (i.v.) in tail, single dose
Result: Significantly decreased mean pulmonary artery pressure (mPAP) dose-dependently.
Significantly reversed hypoxia-induced pulmonary artery remodeling by decreasing the number of smooth muscle cells.
Increased the expression of PTEN compared with that in the normoxia or hypoxia (no treatment) groups.
Molecular Weight

541.56

Formula

C16H20N7NaO7S3
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C(C(N12)=C(CSC3=NN=NN3C)CS[C@]2([H])[C@](OC)(NC(CSC[C@@H](N)C(O)=O)=O)C1=O)O[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

H2O : 83.33 mg/mL (153.87 mM; Need ultrasonic)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.8465 mL 9.2326 mL 18.4652 mL
5 mM 0.3693 mL 1.8465 mL 3.6930 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 50 mg/mL (92.33 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
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g

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(per animal)

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 1.8465 mL 9.2326 mL 18.4652 mL 46.1629 mL
5 mM 0.3693 mL 1.8465 mL 3.6930 mL 9.2326 mL
10 mM 0.1847 mL 0.9233 mL 1.8465 mL 4.6163 mL
15 mM 0.1231 mL 0.6155 mL 1.2310 mL 3.0775 mL
20 mM 0.0923 mL 0.4616 mL 0.9233 mL 2.3081 mL
25 mM 0.0739 mL 0.3693 mL 0.7386 mL 1.8465 mL
30 mM 0.0616 mL 0.3078 mL 0.6155 mL 1.5388 mL
40 mM 0.0462 mL 0.2308 mL 0.4616 mL 1.1541 mL
50 mM 0.0369 mL 0.1847 mL 0.3693 mL 0.9233 mL
60 mM 0.0308 mL 0.1539 mL 0.3078 mL 0.7694 mL
80 mM 0.0231 mL 0.1154 mL 0.2308 mL 0.5770 mL
100 mM 0.0185 mL 0.0923 mL 0.1847 mL 0.4616 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Cefminox sodium Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cefminox75498-96-3MT-141MT141MT 141AntibioticBacterialPPARProstaglandin ReceptorPTENAktmTORPeroxisome proliferator-activated receptorsPhosphatase and tensin homologMMAC1PKBProtein kinase BMammalian target of RapamycinInhibitorinhibitorinhibit

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