2. PI3K/Akt/mTOR Anti-infection MAPK/ERK Pathway
  3. PI4K Parasite MAP4K PI3K
  4. PI4K-IN-3

PI4K-IN-3 (Compound 27) is an orally active PI4K inhibitor with an IC50 of 1.9  nM for Plasmodium vivax PI4K. PI4K-IN-3 has no hERG channel inhibition and mammalian cytotoxicity. PI4K-IN-3 has significant selectivity against the human MINK1 and MAP4K4 kinases but with low selectivity against human PI3Kα and PI4Kβ. PI4K-IN-3 has potent antimalarial activity and significantly reduces parasitaemia in NSG mice mouse models of Plasmodium falciparum malaria.

For research use only. We do not sell to patients.

PI4K-IN-3

PI4K-IN-3 Chemical Structure

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PI4K-IN-3 Related Antibodies

Top Publications Citing Use of Products

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PI4KIIIβ PI4KIIIα PI4K PI4KII

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Amebae Coccidia Leishmania Mite Plasmodium Toxoplasma Trypanosoma Schistosome

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MAP4K2/GCK MAP4K3/GLK MAP4K4/HGK MAP4K5/KHS1 MAP4K6/MINK1 MAP4K7/TNIK MAP4K1/HPK1

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View All Isoforms
PI3Kα PI3Kβ PI3Kγ PI3Kδ PI3KC2α PI3KC2β PI3KC2γ Vps34 PI3K PI3KC3 p120γ

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Description

PI4K-IN-3 (Compound 27) is an orally active PI4K inhibitor with an IC50 of 1.9  nM for Plasmodium vivax PI4K. PI4K-IN-3 has no hERG channel inhibition and mammalian cytotoxicity. PI4K-IN-3 has significant selectivity against the human MINK1 and MAP4K4 kinases but with low selectivity against human PI3Kα and PI4Kβ. PI4K-IN-3 has potent antimalarial activity and significantly reduces parasitaemia in NSG mice mouse models of Plasmodium falciparum malaria[1].

IC50 & Target[1]

MINK1/MAP4K6

>10 μM (IC50)

MAP4K4

>10 μM (IC50)

PvPI4K

1.9 nM (IC50)

Plasmodium

 

PI4KB

0.13 μM (IC50)

PI3Kα

0.07 μM (IC50)

Molecular Weight

412.48

Formula

C25H24N4O2
SMILES

OC(C)(C1=CC=C(C2=C3C(C=CC(C4=CC(CC(NC)=O)=CC=C4)=N3)=NC=C2)C=N1)C
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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PI4K-IN-3 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

PI4K-IN-3PI4KParasiteMAP4KPI3KPhosphatidylinositol 4 kinasesPI4 kinasesMAPK Kinase Kinase KinasePhosphoinositide 3-kinasePlasmodium vivaxAntimalarialNSG mice mouse modelsPlasmodium falciparumInhibitorinhibitorinhibit

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