1. Membrane Transporter/Ion Channel Neuronal Signaling
  2. nAChR
  3. Soclenicant

Soclenicant  (Synonyms: BNC210; IW-2143)

Cat. No.: HY-172236 Purity: 99.75%
Handling Instructions Technical Support

Soclenicant (BNC210) is an orally active α7 nAChR negative alteration modulator (NAM) with no apparent side effects. Soclenicant exhibits acute anxiolytic activity in rodent models of anxiety. Soclenicant inhibits rat and human α7 nAChR currents (in stably transfected cell lines) induced by acetylcholine, nicotine, choline, and the a7-specific agonist PNU-282987 (HY-12560A) with IC50 values in the range of 1.2 to 3 μM. Soclenicant can be used in studies of anxiety, trauma, and stressor-related disorders.

For research use only. We do not sell to patients.

Soclenicant Chemical Structure

Soclenicant Chemical Structure

CAS No. : 1020634-41-6

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Based on 1 publication(s) in Google Scholar

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Description

Soclenicant (BNC210) is an orally active α7 nAChR negative alteration modulator (NAM) with no apparent side effects. Soclenicant exhibits acute anxiolytic activity in rodent models of anxiety. Soclenicant inhibits rat and human α7 nAChR currents (in stably transfected cell lines) induced by acetylcholine, nicotine, choline, and the a7-specific agonist PNU-282987 (HY-12560A) with IC50 values in the range of 1.2 to 3 μM. Soclenicant can be used in studies of anxiety, trauma, and stressor-related disorders[1][2][3][4].

In Vivo

Soclenicant (BNC210) (0.1-10 mg/kg) increases the time spent and the distance travelled in the open arms of the maze in mice[4].

Mean pharmacokinetic parameters following oral administration of Soclenicant (BNC210) to male Sprague Dawley rats at doses of 0.5, 5 and 100 mg/kg[3]

Parameter Measured Dose (mg/kg) Apparent thalf (h) Cmax (μM) Tmax (min) AUC0-tlast (μM*min) AUC0-inf (μM*min) AUC0-inf/D (μM*min*kg/μmol) Apparent BA (%) % Dose in urine
0.5 mg/kg 0.55 c.n.c. 0.2 30 53.8 c.n.c. 41.4 66.7 1.6
5 mg/kg 4.8 8.8 1.1 30/300/30 496.8 497.6 43.7 70.3 0.7
100 mg/kg 102.4 6.3 5.7 150 3055.1 3062.9 12.5 13.2 0.2

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Clinical Trial
Molecular Weight

418.49

Formula

C24H26N4O3

CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C1C2=CC(NC3CC4=C(C3)C=CC=C4)=CN=C2N(CC)C=C1C(N5CCOCC5)=O

Shipping

Room temperature in continental US; may vary elsewhere.

Storage
Powder -20°C 3 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 10 mg/mL (23.90 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 2.3895 mL 11.9477 mL 23.8954 mL
5 mM 0.4779 mL 2.3895 mL 4.7791 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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This equation is commonly abbreviated as: C1V1 = C2V2

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Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 2.3895 mL 11.9477 mL 23.8954 mL 59.7386 mL
5 mM 0.4779 mL 2.3895 mL 4.7791 mL 11.9477 mL
10 mM 0.2390 mL 1.1948 mL 2.3895 mL 5.9739 mL
15 mM 0.1593 mL 0.7965 mL 1.5930 mL 3.9826 mL
20 mM 0.1195 mL 0.5974 mL 1.1948 mL 2.9869 mL
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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

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Soclenicant
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