2. Metabolic Enzyme/Protease
  3. Phosphodiesterase (PDE)
  4. ATX inhibitor 11

ATX inhibitor 11 (compound 13c) is a potent ATX (autotaxin) inhibitor, with an IC50 of 2.7 nM. ATX inhibitor 11 can typically alleviate the severity of fibrosis tissues and effectively reduce the deposition of fibrotic biomarker α-SMA in mice fibrosis model. ATX inhibitor 11 can be used for lung fibrosis research.

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ATX inhibitor 11 Chemical Structure

ATX inhibitor 11 Chemical Structure

CAS No. : 2485779-27-7

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Based on 1 publication(s) in Google Scholar

ATX inhibitor 11 Related Antibodies

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View All Phosphodiesterase (PDE) Isoform Specific Products:

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PDE1 PDE2 PDE3 PDE4 PDE5 PDE6 PDE7 PDE9 PDE10 PDE11 PDE12 PDE8 Autotaxin

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Description

ATX inhibitor 11 (compound 13c) is a potent ATX (autotaxin) inhibitor, with an IC50 of 2.7 nM. ATX inhibitor 11 can typically alleviate the severity of fibrosis tissues and effectively reduce the deposition of fibrotic biomarker α-SMA in mice fibrosis model. ATX inhibitor 11 can be used for lung fibrosis research[1].

IC50 & Target

Autotaxin

2.7 ± 1 nM (IC50)

Molecular Weight

585.65

Formula

C32H35N5O6
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

CCC1=C(N2C=C(C=C(C2=N1)C)C3=CC=C(C=C3)C(N4CCN(CC4)CCO)=O)NC(OCC5=CC6=C(OCO6)C=C5)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage
Powder -20°C 3 years
4°C 2 years
In solvent -80°C 6 months
-20°C 1 month
Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (170.75 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 1.7075 mL 8.5375 mL 17.0750 mL
5 mM 0.3415 mL 1.7075 mL 3.4150 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 1.7075 mL 8.5375 mL 17.0750 mL 42.6876 mL
5 mM 0.3415 mL 1.7075 mL 3.4150 mL 8.5375 mL
10 mM 0.1708 mL 0.8538 mL 1.7075 mL 4.2688 mL
15 mM 0.1138 mL 0.5692 mL 1.1383 mL 2.8458 mL
20 mM 0.0854 mL 0.4269 mL 0.8538 mL 2.1344 mL
25 mM 0.0683 mL 0.3415 mL 0.6830 mL 1.7075 mL
30 mM 0.0569 mL 0.2846 mL 0.5692 mL 1.4229 mL
40 mM 0.0427 mL 0.2134 mL 0.4269 mL 1.0672 mL
50 mM 0.0342 mL 0.1708 mL 0.3415 mL 0.8538 mL
60 mM 0.0285 mL 0.1423 mL 0.2846 mL 0.7115 mL
80 mM 0.0213 mL 0.1067 mL 0.2134 mL 0.5336 mL
100 mM 0.0171 mL 0.0854 mL 0.1708 mL 0.4269 mL
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ATX inhibitor 11 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ATX inhibitor 112485779-27-7ATX inhibitor11ATX inhibitor-11Phosphodiesterase (PDE)Imidazo[1,2-a]pyridineLung fibrosisAutotaxinPhosphodiesteraseENPPHistological sectionsInhibitorinhibitorinhibit

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