2. Cell Cycle/DNA Damage
  3. DNA Alkylator/Crosslinker
  4. trans-Platinum(II)diammine dichloride

trans-Platinum(II)diammine dichloride  (Synonyms: trans-platinumdiamminedichloride)

Cat. No.: HY-W075885 Purity: 99.90%
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trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links.

For research use only. We do not sell to patients.

trans-Platinum(II)diammine dichloride

trans-Platinum(II)diammine dichloride Chemical Structure

CAS No. : 14913-33-8

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Based on 1 publication(s) in Google Scholar

Other Forms of trans-Platinum(II)diammine dichloride:

trans-Platinum(II)diammine dichloride Related Antibodies

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Description

trans-Platinum(II)diammine dichloride (trans-platinumdiamminedichloride) is a geometric isomer of Cisplatin (HY-17394). Trans-Platinum(II)diammine dichloride is a DNA cross-linking agent that induces significant DNA cross-link damage while exhibiting low cytotoxicity. Trans-Platinum(II)diammine dichloride is useful for studying DNA-protein cross-links[1][2].

In Vitro

trans-Platinum(II)diammine dichloride (20-200 μM, 0-24 h) induces DNA cross-linking but does not cause DNA fragmentation, and its cytotoxicity to L1210 cells is approximately one order of magnitude lower than that of Cisplatin[1][2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

trans-Platinum(II)diammine dichloride Related Antibodies
Molecular Weight

300.05

Formula

Cl2H6N2Pt
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

Cl[Pt]Cl.N.N
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Store at room temperature, keep dry and cool

In solvent -80°C 2 years
-20°C 1 year
Purity & Documentation

Purity: 99.90%

SDS (640 KB)

COA (247 KB)

Handling Instructions (2659 KB)
References
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trans-Platinum(II)diammine dichloride Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

trans-Platinum(II)diammine dichloride14913-33-8trans-platinumdiamminedichlorideDNA Alkylator/CrosslinkerDNA-Protein CrosslinkAlkaline ElutionQuantitative ModelCytotoxicityInhibitorinhibitorinhibit

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