2. Apoptosis NF-κB Metabolic Enzyme/Protease Immunology/Inflammation Stem Cell/Wnt JAK/STAT Signaling
  3. Apoptosis Reactive Oxygen Species (ROS) STAT
  4. Cinnamtannin D1

Cinnamtannin D1 is an orally active polyphenolic compound with immunosuppressive activity. Cinnamtannin D1 regulates the balance of Th17/Treg cells by inhibiting AHR expression. Cinnamtannin D1 reduces apoptosis and ROS in INS-1 cells and primary cultured murine islets induced by Palmitic acid (PA) (HY-N0830). Cinnamtannin D1 reduces Th17 cell differentiation via downregulating p-STAT3/RORγt and promotes Treg cell differentiation via upregulating p-STAT5/Foxp3. Cinnamtannin D1 exerts excellent anti-arthritic efficacy in collagen-induced arthritis (CIA) model of mice. Cinnamtannin D1 can be used for the study of rheumatoid arthritis (RA).

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Cinnamtannin D1

Cinnamtannin D1 Chemical Structure

CAS No. : 97233-06-2

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Cinnamtannin D1 Related Antibodies

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Description

Cinnamtannin D1 is an orally active polyphenolic compound with immunosuppressive activity. Cinnamtannin D1 regulates the balance of Th17/Treg cells by inhibiting AHR expression. Cinnamtannin D1 reduces apoptosis and ROS in INS-1 cells and primary cultured murine islets induced by Palmitic acid (PA) (HY-N0830). Cinnamtannin D1 reduces Th17 cell differentiation via downregulating p-STAT3/RORγt and promotes Treg cell differentiation via upregulating p-STAT5/Foxp3. Cinnamtannin D1 exerts excellent anti-arthritic efficacy in collagen-induced arthritis (CIA) model of mice. Cinnamtannin D1 can be used for the study of rheumatoid arthritis (RA)[1][2].

In Vitro

Cinnamtannin D1 (40 μM, 72 h) significantly inhibits Th17 cell differentiation and promotes Treg cell differentiation in naive CD4+T cells from BALB/c mice under Th17 or Treg polarization conditions[1].
Cinnamtannin D1 (40 μM, 72 h) reduces IL-17A level in Th17 cell supernatant and increases IL-10 level in Treg cell supernatant[1].
Cinnamtannin D1 (72 h) significantly inhibits 6-formylindolo[3,2-b] carbazole (FICZ) (HY-12451)-induced Th17 cell differentiation in splenocytes from BALB/c mice[1].
Cinnamtannin D1(20-40 μM, 96 h) dose-dependently inhibits Th17 cell differentiation and decreases AHR protein expression in naive CD4+T cells from BALB/c mice under Th17 polarization conditions[1].
Cinnamtannin D1 (1.56-50 μM, 48 h) dose-dependently increases cell viability in INS-1 cells treated with Palmitic acid (PA) (HY-N0830)[2].
Cinnamtannin D1 (25-50 μM, 48 h) significantly reduces the apoptotic rate and ROS and NO production of INS-1 cells and primary cultured murine islets induced by PA[2].
Cinnamtannin D1 (25-50 μM, 48 h) significantly reduces the phosphorylation of NF-κB and c-Jun N-terminal kinase (JNK) in INS-1 cells[2].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Cinnamtannin D1 Related Antibodies

Western Blot Analysis[2]

Cell Line: INS-1 cells
Concentration: 25, 50 μM
Incubation Time: 48 h
Result: Reduced the phosphorylation of NF-κB and c-Jun N-terminal kinase (JNK) in INS-1 cells.
In Vivo

Cinnamtannin D1 (50 mg/kg, p.o., daily, 4 weeks) exerts excellent anti-arthritic efficacy in DBA/1 mice with collagen-induced arthritis (CIA)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Bovine collagen type II was intradermally injected into the base of the tail of 6-8-week-old male DBA/1 mice for primary immunization[1]
Dosage: 50 mg/kg
Administration: p.o., daily, 4 weeks
Result: Achieved significant alleviation of collagen-induced arthritis (CIA) severity.
Alleviated joint inflammatory cell infiltration and cartilage damage.
Decreased serum levels of CII-specific IgG, IgG2a, IgG3, and inflammatory cytokines (IL-17, IL-6, IL-1β).
Increased serum levels of anti-inflammatory cytokines (IL-10, TGF-β).
reduced the number of IL-17-secreting cells in spleen and draining lymph nodes.
Decreased splenic Th17 cell (CD4+IL-17A+) frequency.
Elevated splenic Treg cell (CD4+CD25+Foxp3+) frequency.
Decreased phospho-STAT3 (Tyr705) expression.
Increased phospho-STAT5 (Tyr649) expression.
Downregulated mRNA levels of Rorc, Il17, Ccr6, Ahr, and Il22.
Upregulated mRNA levels of Foxp3, Il10, and Tgfb.
Molecular Weight

864.76

Formula

C45H36O18
CAS No.
SMILES

O[C@H]1[C@](OC2=CC(O)=C3)(C(C=C4)=CC(O)=C4O)OC(C=C5O)=C(C(O[C@@H]6C(C=C7)=CC(O)=C7O)=C5[C@H](C(C(O)=C8)=C(O[C@H](C(C=C9)=CC(O)=C9O)[C@H]%10O)C(C%10)=C8O)[C@H]6O)[C@@]1([H])C2=C3O
Structure Classification
Initial Source
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
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Cinnamtannin D1 Related Classifications

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  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Cinnamtannin D197233-06-2Cinnamtannin D 1Cinnamtannin D-1ApoptosisReactive Oxygen Species (ROS)STATpancreatic β-cellsapoptosisoxidative stressTh17rheumatoid arthritisInhibitorinhibitorinhibit

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