2. Anti-infection
  3. Beta-lactamase Bacterial
  4. BLI-489

BLI-489 is a beta-lactamase inhibitor. BLI-489 combined with Piperacillin (HY-B1923) inhibits infection caused by class A (including ultra-broad spectrum β-lactamase), Class C (AmpC) and Class D β-lactamase expressing pathogens.

For research use only. We do not sell to patients.

BLI-489 Chemical Structure

BLI-489 Chemical Structure

CAS No. : 623564-40-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in DMSO In-stock
Solid
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5 mg In-stock
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Based on 1 publication(s) in Google Scholar

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BLI-489 Related Antibodies

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Description

BLI-489 is a beta-lactamase inhibitor. BLI-489 combined with Piperacillin (HY-B1923) inhibits infection caused by class A (including ultra-broad spectrum β-lactamase), Class C (AmpC) and Class D β-lactamase expressing pathogens[1].

Molecular Weight

327.29

Formula

C13H10N3NaO4S
CAS No.
Appearance

Solid

Color

Light yellow to yellow

SMILES

O=C(C1=CS[C@@](/C2=C/C3=CN4C(COCC4)=N3)([H])N1C2=O)O[Na]
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

DMSO : ≥ 105 mg/mL (320.82 mM; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.0554 mL 15.2770 mL 30.5539 mL
5 mM 0.6111 mL 3.0554 mL 6.1108 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
×
Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 3.0554 mL 15.2770 mL 30.5539 mL 76.3849 mL
5 mM 0.6111 mL 3.0554 mL 6.1108 mL 15.2770 mL
10 mM 0.3055 mL 1.5277 mL 3.0554 mL 7.6385 mL
15 mM 0.2037 mL 1.0185 mL 2.0369 mL 5.0923 mL
20 mM 0.1528 mL 0.7638 mL 1.5277 mL 3.8192 mL
25 mM 0.1222 mL 0.6111 mL 1.2222 mL 3.0554 mL
30 mM 0.1018 mL 0.5092 mL 1.0185 mL 2.5462 mL
40 mM 0.0764 mL 0.3819 mL 0.7638 mL 1.9096 mL
50 mM 0.0611 mL 0.3055 mL 0.6111 mL 1.5277 mL
60 mM 0.0509 mL 0.2546 mL 0.5092 mL 1.2731 mL
80 mM 0.0382 mL 0.1910 mL 0.3819 mL 0.9548 mL
100 mM 0.0306 mL 0.1528 mL 0.3055 mL 0.7638 mL
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BLI-489 Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

BLI-489623564-40-9BLI489BLI 489Beta-lactamaseBacterialβ-lactamaseCaenorhabditis elegansmouse pneumonia modelInhibitorinhibitorinhibit

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