2. Apoptosis Metabolic Enzyme/Protease
  3. Ferroptosis Mitochondrial Metabolism Glutathione Peroxidase Transferrin Receptor MMP Dihydroorotate Dehydrogenase
  4. OART

OART (Oxaliplatin-artesunate) is a ferroptosis inducer. OART significantly inhibits tumor cell proliferation. OART induces cytoplasmic and mitochondrial LPO to promote tumor ferroptosis, via destroying glutathione-mediated ferroptosis defense system and enhancing iron-dependent Fenton reaction. OART enhances tumor immunogenicity, transforming tumor environment from immunosuppressive to immunosensitive. OART has strong tumor regression in tumor-bearing mouse models. OART can be used for cancer immunotherapy research.

For research use only. We do not sell to patients.

OART

OART Chemical Structure

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OART Related Antibodies

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MMP-1 MMP-2 MMP-3 MMP-8 MMP-9 MMP-13 MMP-14 MMP-17 ADAM10 ADAM17 MMP-7 MMP-12 MMP-10 MMP ADAM8

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Description

OART (Oxaliplatin-artesunate) is a ferroptosis inducer. OART significantly inhibits tumor cell proliferation. OART induces cytoplasmic and mitochondrial LPO to promote tumor ferroptosis, via destroying glutathione-mediated ferroptosis defense system and enhancing iron-dependent Fenton reaction. OART enhances tumor immunogenicity, transforming tumor environment from immunosuppressive to immunosensitive. OART has strong tumor regression in tumor-bearing mouse models. OART can be used for cancer immunotherapy research[1].

Molecular Weight

797.71

Formula

C27H42N2O13Pt+
SMILES

[OH-][Pt+4]12([O-]C(C([O-]2)=O)=O)(OC(CCC(O[C@@H]([C@@H]([C@@]3(CC[C@H]([C@@]4(CC5)[H])C)[H])C)O[C@](O[C@]65C)([C@]34OO6)[H])=O)=O)[NH2][C@@]7([H])[C@](CCCC7)([H])[NH2]1
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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OART Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OARTOxaliplatin-artesunateFerroptosisMitochondrial MetabolismGlutathione PeroxidaseTransferrin ReceptorMMPDihydroorotate DehydrogenaseTfRCD71Matrix metalloproteinasesDHODHCytoplasmicMitochondrialLPO4T1 cellsB16F10 cellsRenca cellsHUVECGlutathioneFenton reactionTumor regressionCancer immunotherapyTumor-bearing mouse modelsInhibitorinhibitorinhibit

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