2. Protein Tyrosine Kinase/RTK MAPK/ERK Pathway PI3K/Akt/mTOR Stem Cell/Wnt Apoptosis
  3. FGFR p38 MAPK Akt ERK Apoptosis
  4. FGFR-IN-23

FGFR-IN-23 (Compound 9p) is a covalent pan FGFR inhibitor with IC50s of 14, 4.2, 5 and 220 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. FGFR-IN-23 also has potent inhibitory activity against gatekeeper mutants, such as FGFR1V561M and FGFR3V555M. FGFR-IN-23 suppresses the activation of FGFR-mediated signaling and induces apoptosis. FGFR-IN-23 shows significant antitumor efficacy in RT112 xenograft mouse models. FGFR-IN-23 can be used for cancers and its drug resistance research.

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FGFR-IN-23

FGFR-IN-23 Chemical Structure

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FGFR-IN-23 Related Antibodies

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Description

FGFR-IN-23 (Compound 9p) is a covalent pan FGFR inhibitor with IC50s of 14, 4.2, 5 and 220 nM for FGFR1, FGFR2, FGFR3 and FGFR4, respectively. FGFR-IN-23 also has potent inhibitory activity against gatekeeper mutants, such as FGFR1V561M and FGFR3V555M. FGFR-IN-23 suppresses the activation of FGFR-mediated signaling and induces apoptosis. FGFR-IN-23 shows significant antitumor efficacy in RT112 xenograft mouse models. FGFR-IN-23 can be used for cancers and its drug resistance research[1].

IC50 & Target[1]

FGFR1

14 nM (IC50)

FGFR2

4.2 nM (IC50)

FGFR3

5 nM (IC50)

FGFR4

220 nM (IC50)

Molecular Weight

496.56

Formula

C27H28N8O2
SMILES

C=CC(NC1=CC2=C(C=C1)C(C3=CNC4=NC=C(C5=CN(CCN6CCOCC6)N=C5)N=C43)=CN2C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FGFR-IN-23 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FGFR-IN-23FGFRp38 MAPKAktERKApoptosisFibroblast growth factor receptorPKBProtein kinase BExtracellular signal regulated kinasesAntitumorRT112 xenograft mouse modelsBa/F3 FGFR2V564F cellsKATO III cellsCancersInhibitorinhibitorinhibit

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