2. Neuronal Signaling Protein Tyrosine Kinase/RTK PI3K/Akt/mTOR Membrane Transporter/Ion Channel
  3. Serotonin Transporter Trk Receptor PI3K Akt mTOR P-glycoprotein
  4. Levomilnacipran hydrochloride

Levomilnacipran hydrochloride  (Synonyms: (1S,2R)-Milnacipran hydrochloride; F-2695 hydrochloride)

Cat. No.: HY-B0168B Purity: 99.95%
COA
SDS
Handling Instructions Technical Support

Levomilnacipran ((1S,2R)-Milnacipran) hydrochloride is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran hydrochloride is a serotonin and norepinephrine reuptake inhibitor, with IC50 values of 10.5 nM and 19.0 nM, and Ki values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran hydrochloride has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression.

For research use only. We do not sell to patients.

Levomilnacipran hydrochloride Chemical Structure

Levomilnacipran hydrochloride Chemical Structure

CAS No. : 175131-60-9

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in Water
ready for reconstitution
 In-stock
Solution
10 mM * 1 mL in Water In-stock
Solid
25 mg In-stock
50 mg In-stock
100 mg In-stock
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Customer Review

Based on 1 publication(s) in Google Scholar

Other Forms of Levomilnacipran hydrochloride:

Levomilnacipran hydrochloride Related Antibodies

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  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Levomilnacipran ((1S,2R)-Milnacipran) hydrochloride is the enantiomer of Milnacipran (HY-B0168) and a strong substrate of P-gp that can cross the blood-brain barrier. Levomilnacipran hydrochloride is a serotonin and norepinephrine reuptake inhibitor, with IC50 values of 10.5 nM and 19.0 nM, and Ki values of 92.2 nM and 1.2 nM for human norepinephrine transporter (NET) and serotonin transporter (SERT), respectively. Levomilnacipran hydrochloride has antidepressant and anxiolytic activities. Levomilnacipran hydrochloride can be used for the research of depression[1][2][3][4].

IC50 & Target[3]

TrkB

 

In Vivo

Levomilnacipran (30 mg/kg; intraperitoneal injection; 10 days) hydrochloride exhibits antidepressant activity in LPS (HY-D1056)-induced depressed rat models[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Adult male Wistar rats aged 9 weeks old (200-220 g) treated LPS (HY-D1056)[3]
Dosage: 30 mg/kg
Administration: Intraperitoneal injection; 10 days
Result: Significantly ameliorated depression-like behaviors, including increasing sucrose preference in the SPT, reducing immobility time and increasing swimming time in the FST, and increasing the time spent in the central area in the OFT.
Improved neuronal synaptic deficits and morphological changes in the hippocampus, upregulated the expression of synaptic-related proteins PSD-95 and Syn, activated the BDNF/TrkB mediated PI3K/Akt/mTOR signaling pathway, and suppressed neuroinflammation by regulating the balance of pro- and anti-inflammatory cytokines in the hippocampus.
Clinical Trial
Molecular Weight

282.81

Formula

C15H23ClN2O
CAS No.
Appearance

Solid

Color

White to off-white

SMILES

O=C([C@]1(C2=CC=CC=C2)[C@H](CN)C1)N(CC)CC.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

4°C, sealed storage, away from moisture

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture)

Solvent & Solubility
In Vitro: 

H2O : ≥ 50 mg/mL (176.80 mM)

*"≥" means soluble, but saturation unknown.

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 3.5359 mL 17.6797 mL 35.3594 mL
5 mM 0.7072 mL 3.5359 mL 7.0719 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

  • Molarity Calculator

  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass
=
Concentration
×
Volume
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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start)

C1

×
Volume (start)

V1

=
Concentration (final)

C2

×
Volume (final)

V2

In Vivo:

For the following dissolution methods, please prepare the working solution directly. It is recommended to prepare fresh solutions and use them promptly within a short period of time.
The percentages shown for the solvents indicate their volumetric ratio in the final prepared solution. If precipitation or phase separation occurs during preparation, heat and/or sonication can be used to aid dissolution.

  • Protocol 1

    Add each solvent one by one:  PBS

    Solubility: 100 mg/mL (353.59 mM); Clear solution; Need ultrasonic

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

Dosage

mg/kg

Animal weight
(per animal)

g

Dosing volume
(per animal)

μL

Number of animals

Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
This product has good water solubility, please refer to the measured solubility data in water/PBS/Saline for details.
The concentration of the stock solution you require exceeds the measured solubility. The following solution is for reference only.If necessary, please contact MedChemExpress (MCE).
Purity & Documentation

Purity: 99.95%

SDS (583 KB)

COA (254 KB) LCMS (260 KB)

Handling Instructions (2659 KB)
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
H2O 1 mM 3.5359 mL 17.6797 mL 35.3594 mL 88.3986 mL
5 mM 0.7072 mL 3.5359 mL 7.0719 mL 17.6797 mL
10 mM 0.3536 mL 1.7680 mL 3.5359 mL 8.8399 mL
15 mM 0.2357 mL 1.1786 mL 2.3573 mL 5.8932 mL
20 mM 0.1768 mL 0.8840 mL 1.7680 mL 4.4199 mL
25 mM 0.1414 mL 0.7072 mL 1.4144 mL 3.5359 mL
30 mM 0.1179 mL 0.5893 mL 1.1786 mL 2.9466 mL
40 mM 0.0884 mL 0.4420 mL 0.8840 mL 2.2100 mL
50 mM 0.0707 mL 0.3536 mL 0.7072 mL 1.7680 mL
60 mM 0.0589 mL 0.2947 mL 0.5893 mL 1.4733 mL
80 mM 0.0442 mL 0.2210 mL 0.4420 mL 1.1050 mL
100 mM 0.0354 mL 0.1768 mL 0.3536 mL 0.8840 mL

* Note: If you choose water as the stock solution, please dilute it to the working solution, then filter and sterilize it with a 0.22 μm filter before use.

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Levomilnacipran hydrochloride Related Classifications

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    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Levomilnacipran175131-60-9(1S,2R)-MilnacipranF-2695F2695F 2695Serotonin TransporterTrk ReceptorPI3KAktmTORP-glycoprotein5-HTTSERTSLC6A4Tropomyosin related kinase receptor Phosphoinositide 3-kinasePKBProtein kinase BMammalian target of RapamycinP-gpPgpMultidrug resistance protein 1MDR1ATP-binding cassette sub-family B member 1ABCB1Cluster of differentiation 243CD243depressed modelsInhibitorinhibitorinhibit

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