2. Metabolic Enzyme/Protease
  3. Liposome
  4. Phospholipid PL1

Phospholipid PL1 is a phospholipid-derived nanoparticle, can deliver costimulatory receptor mRNA (CD137 or OX40) to T cells. Phospholipid PL1 could induce the activation of various immune cells, including T cells and dendritic cells (DCs) in order to boost antitumor immunity.

For research use only. We do not sell to patients.

Phospholipid PL1

Phospholipid PL1 Chemical Structure

CAS No. : 2274812-94-9

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Phospholipid PL1 Related Antibodies

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Description

Phospholipid PL1 is a phospholipid-derived nanoparticle, can deliver costimulatory receptor mRNA (CD137 or OX40) to T cells. Phospholipid PL1 could induce the activation of various immune cells, including T cells and dendritic cells (DCs) in order to boost antitumor immunity[1].

In Vivo

Phospholipid PL1 (10 µg mRNA/mouse; i.t.; 6 times every other day; for 60 d) improves the immunotherapy with an anti-CD137 Ab and antitumor activity with an anti-OX40 Ab in tumor models with better results obtained in the B16F10 melanoma model than the A20 lymphoma model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: B16F10 melanoma mouse model and A20 lymphoma mouse model (C57BL/6 mice)[1]
Dosage: Administration of PL1-CD137 + anti-CD137 Ab; PL1-CD137 (10 µg mRNA/mouse), and anti-CD137 Ab (16 µg/mouse)
Administration: Intratumoral injection; 6 times every other day; 60 days
Result: Dramatically decreased the tumor growth rate by 5-fold (18 days after inoculation), and increased the overall survival time in B16F10 melanoma model.
Resulted in a 2-fold decrease in the tumor growth rate (18d after inoculation) in A20 lymphoma model, without significant extension in the overall survival time.
Animal Model: B16F10 melanoma mouse model and CT26 colon carcinoma mouse model (C57BL/6 mice)[1]
Dosage: Administration of PL1-OX40 + anti-OX40 Ab; PL1-OX40 (10 µg mRNA/mouse), and anti-OX40 Ab (8 µg/mouse)
Administration: Intratumoral injection; 6 times every other day; 60 days
Result: Significantly decreased the tumor growth and prolonged survival in comparison to treatment with PBS and PL1-OX40 + anti-OX40 Ab in both tumor models.
Molecular Weight

1073.59

Formula

C61H121N2O10P
CAS No.
SMILES

O=C(CCCCCCCCN(CCCN(CCCCCCCCC(OC(CCCCC)CC)=O)CCCCCCCCC(OC(CCCCC)CC)=O)CCCOP(OCC)(OCC)=O)OC(CCCCC)CC
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Phospholipid PL1 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Phospholipid PL12274812-94-9Phospholipid PL 1Phospholipid PL-1Liposomebiomimetic phospholipidcostimulatory receptorCD137OX40B16F10 melanoma modelA20 lymphoma modelCT26 colon carcinoma modelInhibitorinhibitorinhibit

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