2. GPCR/G Protein Stem Cell/Wnt JAK/STAT Signaling
  3. LPL Receptor STAT
  4. pro-FTY

pro-FTY, a FTY720 (HY-12005) anticancer prodrug, is a sphingosine-1-phosphate (S1P) (HY-108496) inhibitor. pro-FTY specifically inhibits S1P signaling in cancer cells using a drug delivery system (DDS) that reacts with acrolein. pro-FTY significantly inhibits the survival of breast cancer cells, including multidrug-resistant cells and its organoids resistant to Paclitaxel (HY-B0015) or Doxorubicin (HY-15142A). pro-FTY potently suppresses tumor growth in 4T1 cells or organoids xenograft tumors mice model while avoiding lymphocytopenia.

For research use only. We do not sell to patients.

pro-FTY Chemical Structure

pro-FTY Chemical Structure

CAS No. : 3064707-13-4

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pro-FTY Related Antibodies

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LPAR1 LPAR2 LPAR3 LPAR5 S1PR1 S1PR2 S1PR3 S1PR4 S1PR5

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STAT3 STAT5 STAT6 STAT1

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Description

pro-FTY, a FTY720 (HY-12005) anticancer prodrug, is a sphingosine-1-phosphate (S1P) (HY-108496) inhibitor. pro-FTY specifically inhibits S1P signaling in cancer cells using a drug delivery system (DDS) that reacts with acrolein. pro-FTY significantly inhibits the survival of breast cancer cells, including multidrug-resistant cells and its organoids resistant to Paclitaxel (HY-B0015) or Doxorubicin (HY-15142A). pro-FTY potently suppresses tumor growth in 4T1 cells or organoids xenograft tumors mice model while avoiding lymphocytopenia[1].

IC50 & Target[1]

p-STAT3

 

Molecular Weight

566.77

Formula

C33H50N4O4
CAS No.
SMILES

OCC(NC(OCC1=CC(C(C)C)=C(N=[N+]=[N-])C(C(C)C)=C1)=O)(CO)CCC2=CC=C(CCCCCCCC)C=C2
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References
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pro-FTY Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

pro-FTY3064707-13-4LPL ReceptorSTATLysophospholipid ReceptorAnticancerProdrugFTY720AcroleinSphingosine-1-phosphateS1PDrug delivery systemDDSLymphocytopeniaMDA-MB-468MCF-10 cellsOrganoids4T1 cells xenograft tumors mice modelorganoids xenograft tumors mice modelInhibitorinhibitorinhibit

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