2. Neuronal Signaling
  3. Cholinesterase (ChE)
  4. Nafimidone hydrochloride

Nafimidone is a stable and brain-penetrant antiepileptic compound Nafimidone shows effective anticonvulsant effects in kindled amygdaloid seizure model. However, The effective window of Nafimidone is narrow, and has obvious epileptogenic effects at high doses. Nafimidone can be used for the study of epilepsy.

For research use only. We do not sell to patients.

Nafimidone hydrochloride Chemical Structure

Nafimidone hydrochloride Chemical Structure

CAS No. : 70891-37-1

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

Other Forms of Nafimidone hydrochloride:

Nafimidone hydrochloride Related Antibodies

Top Publications Citing Use of Products

View All Cholinesterase (ChE) Isoform Specific Products:

View All Isoforms
AChE BChE

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

Nafimidone is a stable and brain-penetrant antiepileptic compound Nafimidone shows effective anticonvulsant effects in kindled amygdaloid seizure model. However, The effective window of Nafimidone is narrow, and has obvious epileptogenic effects at high doses. Nafimidone can be used for the study of epilepsy[1].

In Vivo

Nafimidone (25-50mg/kg, i.p., single dose) significantly reduces the duration and severity of afterdis-charge (AD) episodes in Kindled amygdaloid seizure rat model[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Kindled amygdaloid seizures established in Sprague-Dawley rats[1]
Dosage: 0, 3.1, 6.25, 12.5, 25, 50, 100, 120 mg/kg
Administration: Intraperitoneal injection (i.p.), single dose
Result: Significantly reduced in seizure rank and AD duration was noted at 25mg/kg after 30 min.
Resulted in a reduction of elicited seizure rank and a significant reduction in AD duration at 50 mg/kg.
Had drug-induced spontaneous seizures and led to the death of the rats at 100 mg/kg and 120 mg/kg.
Significantly reduced elicited seizure rank scores at 15 and 30 min and return to the control level at 180 minutes at a dose of 25mg/kg.
Molecular Weight

272.73

Formula

C15H13ClN2O
CAS No.
SMILES

O=C(CN1C=NC=C1)C2=CC3=C(C=CC=C3)C=C2.Cl
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

Nafimidone hydrochloride Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Nafimidone70891-37-1Cholinesterase (ChE)(arylalkyl)azoleesterificationkindled amygdaloid seizureAntiepilepticsInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
Nafimidone hydrochloride
Cat. No.:
HY-165514A
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.