2. Epigenetics Apoptosis PROTAC
  3. Small Interfering RNA (siRNA) MDM-2/p53 PROTACs
  4. ZS3-046

ZS3-046 is a TAF1 PROTAC degrader. ZS3-046 promotes the ubiquitination and degradation of TAF1. ZS3-046 activates p53 and induces apoptosis in acute myeloid leukemia (AML) cells. ZS3-046 has antitumor activity in an AML tumor xenograft mouse model. (Target protein ligand (HY-176467); CRBN ligase (HY-41547); Linker (HY-176469); CRBN ligase + Linker (HY-176450)).

For research use only. We do not sell to patients.

ZS3-046 Chemical Structure

ZS3-046 Chemical Structure

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ZS3-046 Related Antibodies

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von Hippel-Lindau (VHL) Cereblon MDM2 cIAP1

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Description

ZS3-046 is a TAF1 PROTAC degrader. ZS3-046 promotes the ubiquitination and degradation of TAF1. ZS3-046 activates p53 and induces apoptosis in acute myeloid leukemia (AML) cells. ZS3-046 has antitumor activity in an AML tumor xenograft mouse model. (Target protein ligand (HY-176467); CRBN ligase (HY-41547); Linker (HY-176469); CRBN ligase + Linker (HY-176450))[1].

Molecular Weight

884.03

Formula

C49H57N9O7
SMILES

O=C(N1C2CCC(NC2=O)=O)C3=C(NCC4CCN(CCCCCCCN5C6=C(C(C(C7=C8NC=C7)=CN(CCC=C)C8=O)=CC(C(N9CCOCC9)=O)=C6)N=C5)CC4)C=CC=C3C1=O
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Room temperature in continental US; may vary elsewhere.
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Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZS3-046 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZS3-046Small Interfering RNA (siRNA)MDM-2/p53PROTACsacute myeloid leukemia (AML)PROTACInhibitorinhibitorinhibit

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