2. Immunology/Inflammation
  3. CD19
  4. GBR-401

GBR-401 is a humanized anti-CD19 monoclonal antibody with high affinity for FcγRIIIa. GBR-401 exerts a potent in vitro and in vivo cytotoxic activity against various B-cell malignancies. GBR-401 induces cell death by antibody dependent cellular cytotoxicity (ADCC) and direct killing effect. GBR-401 demonstrates potent activity of depleting malignant B cells and prolongs mice survival in multiple xenograft severe combined immunodeficiency (SCID) mice models.

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GBR-401 Chemical Structure

GBR-401 Chemical Structure

CAS No. : 1931954-95-8

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GBR-401 Related Antibodies

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Description

GBR-401 is a humanized anti-CD19 monoclonal antibody with high affinity for FcγRIIIa. GBR-401 exerts a potent in vitro and in vivo cytotoxic activity against various B-cell malignancies. GBR-401 induces cell death by antibody dependent cellular cytotoxicity (ADCC) and direct killing effect. GBR-401 demonstrates potent activity of depleting malignant B cells and prolongs mice survival in multiple xenograft severe combined immunodeficiency (SCID) mice models[1].

IC50 & Target

CD19
In Vitro

GBR-401 (0.00001-1 µg/ mL, 4-24 h) displays a markedly superior ADCC activity on malignant B cells and primary CLL and lymphoma samples[1].

GBR-401 shows EC50 values of 1.2 ng/mL (Raji), 0.9 ng/mL (Ramos), 0.8 ng/mL (SU-DHL-6), 2 ng/mL (Namalwa), 1.6 ng/mL (B-CLL) and 15 ng/mL (Lymphoma) for ADCC[1].

GBR-401 (0.1-5 μg/mL, 2 h) resultes in a rapid increase in the proportion of late apoptotic/necrotic dead in Mec-1, Raji and SU-DHL-6 cell lines[1].

GBR-401 induces cell death by inducing a rapid and strong homotypic aggregation through actin reorganization in Raji cells[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

GBR-401 Related Antibodies
In Vivo

GBR-401 (0.005-10 mg/kg, i.p., a single dose) depletes B cells in human PBMCs cells xenograft mice models[1].

GBR-401 (2 mg/kg, i.p., a single dose) significantly reduces B-CLL cells in human CLL cells xenograft mice models[1].

GBR-401 (2 mg/kg, for 3 times at day 3, 7 and 10) prolongs median survival time and increases mice survival in Raji cells xenograft mice models[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: Human PBMCs cells xenograft mice models (SCID mice, 8 weeks)[1]
Dosage: 0.005, 0.02, 0.1, 0.5, 2 and 10 mg/kg
Administration: Intraperitoneal injection
Result: Showed an EC50 value of 0.03 mg/kg and a maximum efficacy from 2 mg/kg with 84% reduction of the B cell population after 4 days.
Animal Model: Patient derived CLL and purified NK cells from healthy donors xenograft mice models (SCID mice, 8 weeks)[1]
Dosage: 2 mg/kg
Administration: Intraperitoneal injection
Result: Displayed a dramatic and significant reduction (92%) of B-CLL cells in the peritoneal cavity.
Animal Model: Raji cells xenograft mice models (SCID mice, 8 weeks)[1]
Dosage: 2 mg/kg
Administration: for 3 times at day 3, 7 and 9
Result: Significantly prolonged median survival time (51 days) and increased mice survival by 2.1 fold.
Gene ID

930  [NCBI]

Accession
Target

CD19
Application

ELISA, FACS, Functional assay
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
CAS No.
SMILES

N/A
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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GBR-401 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

GBR-4011931954-95-8GBR401GBR 401CD19B cell malignancies Anti-CD19 monoclonal antibodyADCCTherapeutic antibodyInhibitorinhibitorinhibit

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