2. Membrane Transporter/Ion Channel Neuronal Signaling
  3. Calcium Channel
  4. HM12

HM12 is a covalent inhibitor of L-/T-type calcium channels. HM12 can strongly inhibit the Cav1.2 (L-type) and Cav3.2 (T-type) calcium channels, and has selectivity for the N-type channels. HM12 produces an irreversible inhibition that persisted after washout. HM12 can be used to study diseases such as hypertension, pain, epilepsy, etc.

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HM12

HM12 Chemical Structure

CAS No. : 2376051-91-9

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HM12 Related Antibodies

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N-type calcium channel L-type calcium channel P/Q-type calcium channel T-type calcium channel Calcium Channel

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Description

HM12 is a covalent inhibitor of L-/T-type calcium channels. HM12 can strongly inhibit the Cav1.2 (L-type) and Cav3.2 (T-type) calcium channels, and has selectivity for the N-type channels. HM12 produces an irreversible inhibition that persisted after washout. HM12 can be used to study diseases such as hypertension, pain, epilepsy, etc[1].

IC50 & Target[1]

Cav1.2

 

Cav3.2

 

In Vitro

HM12 (10 μM) exhibits > 90% inhibitory activity against the Cav3.2 calcium channel and > 60% inhibitory activity against the Cav1.2 calcium channel[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

HM12 Related Antibodies
Molecular Weight

597.29

Formula

C25H27Br2NO6
CAS No.
SMILES

O=C(C1=C(C)NC2=C(C(C(C)(C)CC2)=O)C1C3=CC(Br)=CC(Br)=C3O)OCCOC(C(C)=C)=O
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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HM12 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
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The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

HM122376051-91-9HM 12HM-12Calcium ChannelCa2+ channelsCa channelsDihydropyridineHexahydroquinolineCalcium channel blockerWhole-cell patch clampCovalent bindingMolecular modelingInhibitorinhibitorinhibit

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