2. Antibody-drug Conjugate/ADC Related
  3. Drug-Linker Conjugates for ADC
  4. OBI-992 drug-linker

OBI-992 drug-linker is a drug-linker conjugate composed of a TOP I inhibitor Exatecan (HY-13631) and a linker. OBI-992 drug-linker exhibits antitumor property in mouse models and can be used for synthesis of ADC OBI-992.

For research use only. We do not sell to patients.

OBI-992 drug-linker Chemical Structure

OBI-992 drug-linker Chemical Structure

CAS No. : 3039487-10-7

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Based on 1 publication(s) in Google Scholar

OBI-992 drug-linker Related Antibodies

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Description

OBI-992 drug-linker is a drug-linker conjugate composed of a TOP I inhibitor Exatecan (HY-13631) and a linker. OBI-992 drug-linker exhibits antitumor property in mouse models and can be used for synthesis of ADC OBI-992[1].

Molecular Weight

2173.46

Formula

C106H162FN9O37
CAS No.
Appearance

Solid

Color

White to yellow

SMILES

O=C(C=CC1=O)N1CC2CCC(C(N[C@@H](CCC(N[C@H](C(N[C@H](C(NC3=CC=C(COC(N[C@H]4CCC5=C6C4=C7C(C(N8C7)=CC([C@](CC)(O)C(OC9)=O)=C9C8=O)=NC6=CC(F)=C5C)=O)C=C3)=O)C)=O)C(C)C)=O)C(NCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOCCOC)=O)=O)CC2
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

-20°C, sealed storage, away from moisture and light

*In solvent : -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light)

Solvent & Solubility
In Vitro: 

DMSO : 100 mg/mL (46.01 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

Preparing
Stock Solutions
Concentration Solvent Mass 1 mg 5 mg 10 mg
1 mM 0.4601 mL 2.3005 mL 4.6010 mL
5 mM 0.0920 mL 0.4601 mL 0.9202 mL
View the Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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  • Dilution Calculator

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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Molecular Weight *

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

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Volume (start)

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Concentration (final)

C2

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V2

In Vivo Dissolution Calculator
Please enter the basic information of animal experiments:

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Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
Calculation results:
Working solution concentration: mg/mL
Purity & Documentation
References

Complete Stock Solution Preparation Table

* Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month (sealed storage, away from moisture and light). When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
DMSO 1 mM 0.4601 mL 2.3005 mL 4.6010 mL 11.5024 mL
5 mM 0.0920 mL 0.4601 mL 0.9202 mL 2.3005 mL
10 mM 0.0460 mL 0.2300 mL 0.4601 mL 1.1502 mL
15 mM 0.0307 mL 0.1534 mL 0.3067 mL 0.7668 mL
20 mM 0.0230 mL 0.1150 mL 0.2300 mL 0.5751 mL
25 mM 0.0184 mL 0.0920 mL 0.1840 mL 0.4601 mL
30 mM 0.0153 mL 0.0767 mL 0.1534 mL 0.3834 mL
40 mM 0.0115 mL 0.0575 mL 0.1150 mL 0.2876 mL
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OBI-992 drug-linker Related Classifications

Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

OBI-992 drug-linker3039487-10-7Drug-Linker Conjugates for ADCBxPC-3NCI-N87MDA-MB-231Inhibitorinhibitorinhibit

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