2. Immunology/Inflammation
  3. Interleukin Related
  4. Anti-Mouse IL-27 p28 Antibody (MM27.7B1)

Anti-Mouse IL-27 p28 Antibody (MM27.7B1) 

Cat. No.: HY-P990215 Purity: 95.00%
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Anti-Mouse IL-27 p28 Antibody (MM27.7B1) is a mouse-derived anti-mouse IL-27 p28 IgG2a, κ type antibody inhibitor. Anti-Mouse IL-27 p28 Antibody (MM27.7B1) can neutralize IL-27. Anti-Mouse IL-27 p28 Antibody (MM27.7B1) delays CD8+ T cell reconstitution mediated by IL-27 after murine anti-thymocyte globulin (mATG) treatment in BALB/c heart allografts mice models.

For research use only. We do not sell to patients.

Anti-Mouse IL-27 p28 Antibody (MM27.7B1) Chemical Structure

Anti-Mouse IL-27 p28 Antibody (MM27.7B1) Chemical Structure

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Description

Anti-Mouse IL-27 p28 Antibody (MM27.7B1) is a mouse-derived anti-mouse IL-27 p28 IgG2a, κ type antibody inhibitor. Anti-Mouse IL-27 p28 Antibody (MM27.7B1) can neutralize IL-27. Anti-Mouse IL-27 p28 Antibody (MM27.7B1) delays CD8+ T cell reconstitution mediated by IL-27 after murine anti-thymocyte globulin (mATG) treatment in BALB/c heart allografts mice models[1][2][3].

IC50 & Target

IL-27 p28
In Vitro

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse IL-27 p28 Antibody (MM27.7B1) Related Antibodies
In Vivo

Anti-Mouse IL-27 p28 Antibody (MM27.7B1) (0.25 mg, i.p., on days 6 and 11 after transplant) delays CD8+ T cell reconstitution mediated by IL-27 after murine anti-thymocyte globulin (mATG) treatment in BALB/c heart allografts mice models[1].
Anti-Mouse IL-27 p28 Antibody (MM27.7B1) (500 μg/mouse, i.p., at day 0 and 5 after infection) suppresses the protection of IL-27 for viral myocarditis in CVB3 (Coxsackie virus B3) infectious mice models. [3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6J mice were transplanted with BALB/c heart allografts and treated with either mATG[1]
Dosage: 0.25 mg
Administration: Intraperitoneally injection, at days 6 and 11 after transplant
Result: Inhibited CD8+ T cell expansion measured on days 12 and 16.
Did not affect reconstitution of CD4+ T lymphocytes.
Abrogated the upregulated expression of IL-7Rα chain on CD8+ T cells caused by lymphoablation.
Animal Model: Viral myocarditis mice models (BALB/c mice, 6-8 weeks) [3]
Dosage: 500 μg/mouse
Administration: Intraperitoneally injection, at day 0 and 5 after CVB3 (Coxsackie virus B3) infection
Result: Accelerated the development of myocarditis and exacerbated the severity.
Declined survival rate of mice.
Showed marked and continuous bodyweight loss.
Increased the percentage of Th17 cells and the levels of IL-17A, TNF-α and IL-6 proteins
Gene ID

50498  [NCBI] & 246779  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse IL-27 p28 Antibody (MM27.7B1)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation

Purity: 95.00%

SDS (251 KB)

COA (232 KB)

Inhibitory Antibodies User Guide (602 KB)
References
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Anti-Mouse IL-27 p28 Antibody (MM27.7B1) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse IL-27 p28 Antibody (MM27.7B1)Interleukin RelatedILIL-27CD8T cellmATGViral myocarditisCVB3Inhibitorinhibitorinhibit

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