2. GPCR/G Protein Immunology/Inflammation
  3. CCR
  4. RO5234444

RO5234444 is an orally active CCR2 antagonist, with IC50s of 22nM for human CCR2 and 161 nM for mouse CCR2. RO5234444 alleviates glomerulosclerosis, reduces albuminuria, and significantly improves the glomerular filtration rate (GFR) in the uninephrectomized (1K) type 2 diabetic db/db mouse model. RO5234444 can be used for the study of type 2 diabetic nephropathy.

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RO5234444

RO5234444 Chemical Structure

CAS No. : 1365266-79-0

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RO5234444 Related Antibodies

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CCR1 CCR2 CCR3 CCR4 CCR5 CCR6 CCR7 CCR8 CCR9

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Description

RO5234444 is an orally active CCR2 antagonist, with IC50s of 22nM for human CCR2 and 161 nM for mouse CCR2. RO5234444 alleviates glomerulosclerosis, reduces albuminuria, and significantly improves the glomerular filtration rate (GFR) in the uninephrectomized (1K) type 2 diabetic db/db mouse model. RO5234444 can be used for the study of type 2 diabetic nephropathy[1].

IC50 & Target[1]

Human CCR2

22 nM (IC50)

Mouse CCR2

161 nM (IC50)

Molecular Weight

463.97

Formula

C24H31ClFN3O3
CAS No.
SMILES

O=C1N(CCCN(CC2)C[C@@H](O)C32CC3)CCN(C(/C=C/C4=CC=C(F)C(Cl)=C4)=O)[C@H]1C
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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RO5234444 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

RO52344441365266-79-0RO 5234444RO-5234444CCRCC chemokine receptorCCR2type 2 diabetic nephropathyglomerulosclerosisInhibitorinhibitorinhibit

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