2. Anti-infection
  3. HBV
  4. VNRX-9945

VNRX-9945 is a potent, broadly and orally active HBV CAM (capsid assembly modulator) with an EC50 of 2.6 nM. VNRX-9945 exhibits excellent and broad antiviral activity against multiple HBV genotypes in vitro, along with favorable pharmacokinetic profiles across multiple species. VNRX-9945 demonstrates robust antiviral efficacy in the adeno-associated virus mice models of HBV (AAV-HBV) infection.

For research use only. We do not sell to patients.

VNRX-9945 Chemical Structure

VNRX-9945 Chemical Structure

CAS No. : 2396680-45-6

Size Stock
50 mg   Get quote  
100 mg   Get quote  
250 mg   Get quote  

* Please select Quantity before adding items.

This product is a controlled substance and not for sale in your territory.

VNRX-9945 Related Antibodies

Top Publications Citing Use of Products

  • Biological Activity

  • Purity & Documentation

  • References

  • Customer Review

Description

VNRX-9945 is a potent, broadly and orally active HBV CAM (capsid assembly modulator) with an EC50 of 2.6 nM. VNRX-9945 exhibits excellent and broad antiviral activity against multiple HBV genotypes in vitro, along with favorable pharmacokinetic profiles across multiple species. VNRX-9945 demonstrates robust antiviral efficacy in the adeno-associated virus mice models of HBV (AAV-HBV) infection[1].

In Vitro

VNRX-9945 (Compound 12) demonstrates robust pan-genotypic of HBV (A-H) antiviral activity with a mean EC50 range 3 to 31 nM[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

VNRX-9945 Related Antibodies
In Vivo

VNRX-9945 (10-100 mg/kg, i.g., bid for 8 weeks) demonstrates robust antiviral efficacy in the adeno-associated virus mice models of HBV (AAV-HBV) infection[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: AAV-HBV mice models (C57BL/6)[1]
Dosage: 10, 30, and 100 mg/kg
Administration: Oral gavage, twice daily for 8 weeks.
Result: Resulted in a significant, dose-dependent reduction in circulating HBV DNA and HBV pgRNA levels.
Led to a > 3 log10 reduction in HBV DNA and an ∼ 2 log10 reduction in HBV pgRNA from baseline at 100 mg/kg.
Showed no changes in HBsAg and HBeAg levels, body weight and ALT levels.
Molecular Weight

429.48

Formula

C23H28FN3O4
CAS No.
SMILES

O=C(C1=C(C)N(C)C(C(C(N[C@H]2CC[C@@H](O)CC2)=O)=O)=C1C)NC3=CC=C(F)C(C)=C3
Shipping

Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
  • No file chosen (Maximum size is: 1024 Kb)
  • If you have published this work, please enter the PubMed ID.
  • Your name will appear on the site.

VNRX-9945 Related Classifications

  • Molarity Calculator

  • Dilution Calculator

The molarity calculator equation

Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

Mass   Concentration   Volume   Molecular Weight *
= × ×

The dilution calculator equation

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

This equation is commonly abbreviated as: C1V1 = C2V2

Concentration (start) × Volume (start) = Concentration (final) × Volume (final)
× = ×
C1   V1   C2   V2
Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

VNRX-99452396680-45-6VNRX9945VNRX 9945HBVHepatitis B virusCAMAAV-HBVInhibitorinhibitorinhibit

Your Recently Viewed Products:

Inquiry Online

Your information is safe with us. * Required Fields.

Product Name

  

Requested Quantity *

Applicant Name *

 

Salutation

Email Address *

 

Phone Number *

Department

 

Organization Name *

City

State

Country or Region *

      

Remarks

Bulk Inquiry

Inquiry Information

Product Name:
VNRX-9945
Cat. No.:
HY-174819
Quantity:
MCE Japan Authorized Agent:

Customer Review

Thank You for Your Feedback!

Request for HNMR Report

Please fill out this form to request the QC report. We will send it to your Email address shortly.

Your information is safe with us. * Required Fields.

Product Name

  

Lot #

Applicant Name *

 

Email Address *

Phone Number

 

Department *

Organization Name *

 

Country or Region *

Remarks

SAFETY DATA SHEET (SDS)

Request for HNMR Report

We have received your request and will respond to you as soon as possible.