2. PI3K/Akt/mTOR Stem Cell/Wnt NF-κB Neuronal Signaling
  3. GSK-3 NF-κB Amyloid-β
  4. Cromolyn

Cromolyn  (Synonyms: Cromoglycate; Cromoglicic acid; FPL-670 free acid)

Cat. No.: HY-B1619 Purity: 99.91%
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Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC50 of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects.

For research use only. We do not sell to patients.

Cromolyn Chemical Structure

Cromolyn Chemical Structure

CAS No. : 16110-51-3

Size Price Stock Quantity
Solid + Solvent (Highly Recommended)
10 mM * 1 mL in DMSO
ready for reconstitution
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10 mM * 1 mL in DMSO In-stock
Solid
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10 mg In-stock
25 mg In-stock
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Customer Review

Based on 8 publication(s) in Google Scholar

Other Forms of Cromolyn:

Cromolyn Related Antibodies

Top Publications Citing Use of Products

    Cromolyn purchased from MedChemExpress. Usage Cited in: Pharmacol Res. 2017 Nov;125(Pt B):150-160.  [Abstract]

    The IL-33 production in different treatment groups is determined in rat skin by immunohistochemistry assay.

    View All GSK-3 Isoform Specific Products:

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    GSK-3 GSK-3α GSK-3β

    View All NF-κB Isoform Specific Products:

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    NF-κB NF-κB1/p50 RelA/p65 RelB c-Rel

    • Biological Activity

    • Purity & Documentation

    • References

    • Customer Review

    Description

    Cromolyn (Cromoglycate) is an orally active GSK-3β inhibitor with an IC50 of 2.0 μM. Cromolyn is also a mast cell stabilizer that can inhibit the release of mediators from mast cells, regulate reflex bronchoconstriction, and reduce non-specific bronchial hyperreactivity, and Cromolyn can be used in the research of bronchial asthma. In addition, Cromolyn has multiple activities such as anti-inflammatory, anti-allergic, anti-histamine, anti-cancer, and neuroprotective effects[1][2][3][4][5].

    In Vitro

    Cromolyn (0-100 μM; 3-10 min) can inhibit IgE- and antigen-induced degranulation and PGD2 synthesis in rat peritoneal mast cells[1].
    Cromolyn (0-100 μM; 0-72 h) can block S100P-promoted cell proliferation, invasion, and increased NF-κB activity in Panc-1 cells[2].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Cromolyn Related Antibodies
    In Vivo

    Cromolyn (10 mg/kg; intravenous injection; single dose) can significantly inhibit mast cell activation in IgE-dependent PCA by reducing Evans blue extravasation and completely inhibit antigen-induced plasma histamine increase in PSA in rats[1].
    Cromolyn (5 mg/kg; intraperitoneal injection; 5 weeks) has anti-tumor activity in a mouse model of pancreatic cancer[2].
    Cromolyn (6.3 mg/kg; intraperitoneal injection; 5 times a week; from postnatal day 60 until euthanasia) has an ameliorative effect in a model of amyotrophic lateral sclerosis[3].
    Cromolyn (1-3.15 mg/kg; intraperitoneal injection; 3 times a week; 12 weeks) has a neuroprotective effect in a mouse model of Alzheimer's disease[4].
    Cromolyn (1.43-5.72 mg/kg; intraperitoneal injection; 1 month) has a hypoglycemic effect in mice[5].

    MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

    Animal Model: Male CB17 scid mice aged 4 weeks old treated BxPC-3 and MPanc-96 cells[2]
    Dosage: 5 mg/kg
    Administration: Intraperitoneal injection; 5 weeks
    Result: Significantly reduced tumor burden.
    Reduced lung metastasis in the BxPC-3 model and both liver and lung metastases in the MPanc-96 model.
    Had no effect on body weight.
    Animal Model: SOD1G93A mice[3]
    Dosage: 6.3 mg/kg
    Administration: Intraperitoneal injection; 5 times a week; from postnatal day 60 until euthanasia
    Result: Delays disease onset.
    Improved motor deficits in the PaGE task.
    Increased survival of lumbar spinal cord motor neurons, decreased denervation at the neuromuscular junction.
    Reduced pro-inflammatory cytokine and chemokine levels in the spinal cord and plasma.
    Decreased mast cell degranulation in the tibialis anterior muscle.
    Animal Model: APPSwedish expressing Tg2576 mice[4]
    Dosage: 1 and 3.15 mg/kg
    Administration: Intraperitoneal injection; 3 times a week; 12 weeks
    Result: Reduced the levels of Aβ40 and Aβ42 in brain TBS-insoluble fractions.
    Increased the level of Aβ38.
    Promoted the phagocytosis of β-amyloid by microglia.
    Animal Model: Normal Balb/c mice, chronic type II diabetic Balb/c mice, and chronic obese Balb/c mice[5]
    Dosage: 1.43, 2.86 and 5.72 mg/kg
    Administration: Intraperitoneal injection; 1 month
    Result: Dose-dependently reducted blood glucose, body weight, and resistin levels.
    Increased liver glycogen, insulin, C-peptide, and adiponectin levels in mice.
    Clinical Trial
    Molecular Weight

    468.37

    Formula

    C23H16O11
    CAS No.
    Appearance

    Solid

    Color

    Off-white to light yellow

    SMILES

    OC(COC1=C2C(C=C(C(O)=O)OC2=CC=C1)=O)COC3=C4C(C=C(C(O)=O)OC4=CC=C3)=O
    Shipping

    Room temperature in continental US; may vary elsewhere.
    Storage
    Powder -20°C 3 years
    4°C 2 years
    In solvent -80°C 6 months
    -20°C 1 month
    Solvent & Solubility
    In Vitro: 

    DMSO : 175 mg/mL (373.64 mM; Need ultrasonic; Hygroscopic DMSO has a significant impact on the solubility of product, please use newly opened DMSO)

    Preparing
    Stock Solutions
    Concentration Solvent Mass 1 mg 5 mg 10 mg
    1 mM 2.1351 mL 10.6753 mL 21.3506 mL
    5 mM 0.4270 mL 2.1351 mL 4.2701 mL
    View the Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

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    Mass (g) = Concentration (mol/L) × Volume (L) × Molecular Weight (g/mol)

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    Concentration (start) × Volume (start) = Concentration (final) × Volume (final)

    This equation is commonly abbreviated as: C1V1 = C2V2

    Concentration (start)

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    In Vivo Dissolution Calculator
    Please enter the basic information of animal experiments:

    Dosage

    mg/kg

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    (per animal)

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    Dosing volume
    (per animal)

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    Number of animals

    Recommended: Prepare an additional quantity of animals to account for potential losses during experiments.
    Calculation results:
    Working solution concentration: mg/mL
    Purity & Documentation
    References

    Complete Stock Solution Preparation Table

    * Please refer to the solubility information to select the appropriate solvent. Once prepared, please aliquot and store the solution to prevent product inactivation from repeated freeze-thaw cycles.
    Storage method and period of stock solution: -80°C, 6 months; -20°C, 1 month. When stored at -80°C, please use it within 6 months. When stored at -20°C, please use it within 1 month.

    Optional Solvent Concentration Solvent Mass 1 mg 5 mg 10 mg 25 mg
    DMSO 1 mM 2.1351 mL 10.6753 mL 21.3506 mL 53.3766 mL
    5 mM 0.4270 mL 2.1351 mL 4.2701 mL 10.6753 mL
    10 mM 0.2135 mL 1.0675 mL 2.1351 mL 5.3377 mL
    15 mM 0.1423 mL 0.7117 mL 1.4234 mL 3.5584 mL
    20 mM 0.1068 mL 0.5338 mL 1.0675 mL 2.6688 mL
    25 mM 0.0854 mL 0.4270 mL 0.8540 mL 2.1351 mL
    30 mM 0.0712 mL 0.3558 mL 0.7117 mL 1.7792 mL
    40 mM 0.0534 mL 0.2669 mL 0.5338 mL 1.3344 mL
    50 mM 0.0427 mL 0.2135 mL 0.4270 mL 1.0675 mL
    60 mM 0.0356 mL 0.1779 mL 0.3558 mL 0.8896 mL
    80 mM 0.0267 mL 0.1334 mL 0.2669 mL 0.6672 mL
    100 mM 0.0214 mL 0.1068 mL 0.2135 mL 0.5338 mL
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    Cromolyn Related Classifications

    Help & FAQs
    • Do most proteins show cross-species activity?

      Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

    Keywords:

    Cromolyn16110-51-3Cromoglycate Cromoglicic acidFPL-670FPL670FPL 670GSK-3NF-κBAmyloid-βGlycogen synthase kinase-3Glycogen synthase kinase 3Nuclear factor-κBNuclear factor-kappaBβ-amyloid peptideAβAbetapancreatic cancer modelamyotrophic lateral sclerosis modelAlzheimer's disease modelrat peritoneal mast cellsPanc-1 cellsInhibitorinhibitorinhibit

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