2. Immunology/Inflammation
  3. Transmembrane Glycoprotein
  4. Anti-Mouse CD70 Antibody (FR70)

Anti-Mouse CD70 Antibody (FR70) 

Cat. No.: HY-P990264 Purity: 95.00%
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Anti-Mouse CD70 Antibody (FR70) is a rat-derived ant-mouse CD70 IgG2b κ type antibody inhibitor. Anti-Mouse CD70 Antibody (FR70) decreases CD4+, CD8+ T cells and eosinophils. Anti-Mouse CD70 Antibody (FR70) shows potent anti-inflammatory and anti-immune effects on allergic lung inflammation and cardiac transplant mice models.

For research use only. We do not sell to patients.

Anti-Mouse CD70 Antibody (FR70) Chemical Structure

Anti-Mouse CD70 Antibody (FR70) Chemical Structure

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Description

Anti-Mouse CD70 Antibody (FR70) is a rat-derived ant-mouse CD70 IgG2b κ type antibody inhibitor. Anti-Mouse CD70 Antibody (FR70) decreases CD4+, CD8+ T cells and eosinophils. Anti-Mouse CD70 Antibody (FR70) shows potent anti-inflammatory and anti-immune effects on allergic lung inflammation and cardiac transplant mice models[1][2][3].

Isotype

Rat IgG2b kappa
Recommend Isotype Controls
IC50 & Target

CD70
In Vitro

The antibody framework is stable, specific and adaptable, and has the ability to bind both antigens and endogenous immune receptors. Monoclonal antibodies have several derivatives, including bispecific antibodies, antibody-drug conjugates, and antibody fragments, and have significant effects in fields such as immunology and oncology. When designing inhibitory antibodies, considerations include identification of antigen-specific variable regions, choice of expression system, use of multispecific formats, and antibody derivatives based on fragmentation, oligomerization, or conjugation with other functional moieties[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Anti-Mouse CD70 Antibody (FR70) Related Antibodies
In Vivo

Anti-Mouse CD70 Antibody (FR70) (500 μg on the day of transplantation and 250 μg/dose on days 2, 4, and 6 posttransplantation, i.p.) significantly prolongs graft survival and reduces the infiltration of CD4+ and CD8+ T cells into the allograft in naive heart transplant mice.[1].
Anti-Mouse CD70 Antibody (FR70) (500 μg on the day of transplantation and 250 μg/dose on days 1, 3, and 5 posttransplantation, i.p.) causes long-term mouse cardiac allograft acceptance with induction of tolerogenic dendritic cells[2].
Anti-Mouse CD70 Antibody (FR70) (300 μg, i.p., at days 0, 2, 4, 7, 11, 14, 16, 18, 22, 25, and 28) shows a potent inhibition of the inflammatory response in a murine model of allergic lung inflammation[3].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: C57BL/6 (H-2b) mice transplanted with fully major histocompatibility complexmismatched BALB/c (H-2d) vascularized cardiac grafts (6-8weeks)[1]
Dosage: 500 μg on the day of transplantation and 250 μg/dose on days 2, 4, and 6 posttransplantation
Administration: Intraperitoneally injection for 4 times
Result: Significant prolonged graft survival.
Reduced the infiltration of CD8+ and CD4+ T cells into the graft at day 8.
Showed low levels of CD8+ and CD4+ T cells in grafts harvested at day 15.
Resulted in lower levels of donor-specific IgG in the sera derived from peripheral blood.
Decreased percentage of splenic CD4+CD25+Foxp3+ cells.
Animal Model: C3H recipient mice with B6 heterotopic cardiac transplantation (8-12 weeks)[2]
Dosage: 500 μg on the day of transplantation and 250 μg/dose on days 1, 3, and 5 posttransplantation
Administration: Intraperitoneally injection for 4 times
Result: Induced long term cardiac allograft acceptance, with an MST of about 100 days.
Had a significantly smaller population of cytotoxic CD8+ T cells in graft-infiltrating lymphocytes and Spleen at day 7.
Decreased the expression of perforin and IFN-γ in the spleen.
Downregulated the expression of CD40, CD80, CD86, IL-6, IL-12β and MHC class II proteins and upregulated the levels of PD-L1, heme oxygenase-1 (HO-1) and indoleamine 2,3-dioxygenase (IDO1).
Generated regulatory cells (Tregs).
Increased the population of CD25+ Foxp3+ cells and levels of Foxp3 mRNA and IL-10 among the CD4+ graft-infiltrating lymphocytes.
Animal Model: Allergic lung inflammation mice models induced by ovalbumin (BALB/cByJJcl, female, 6-8 weeks) [3]
Dosage: 300μg
Administration: Intraperitoneally injection, at days 0, 2, 4, 7, 11, 14, 16, 18, 22, 25, and 28
Result: Significantly reduced the accumulation of eosinophils and lymphocytesand production of Th2 cytokines (IL-4 and IL-13) in BAL fluid and eosinophilia and mucus overproduction in the lung.
Reduced the ovalbumin-specific proliferative response and the levels of IL-4, IL-5, and IL-13.
Significantly inhibited the development of airway hyperreactivity, the accumulation of eosinophils in the lung, and the ovalbumin-specific proliferative response and production of Th2 cytokines (IL-5 and IL-13) in LN cells.
Inhibited the development of CD272 Th2 Cells.
Gene ID

21948  [NCBI]

Accession
Application

ELISA, FACS, Functional assay, Research in vivo
Conjugated

Unconjugated
Reconsititution

The product can be reconstituted/diluted with sterile PBS or saline.
Molecular Weight

150 kDa

Appearance

Liquid

Color

Colorless to light yellow

SMILES

[Anti-Mouse CD70 Antibody (FR70)]
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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Anti-Mouse CD70 Antibody (FR70) Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

Anti-Mouse CD70 Antibody (FR70)Transmembrane GlycoproteinCD70CD4+ T cellsCD8+ T cellsEosinophilsLung inflammationCardiac transplantInhibitorinhibitorinhibit

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