2. Cytoskeleton
  3. Myosin
  4. MT-228

MT-228 is a selective and blood-brain barrier permeable non-muscle myosin II inhibitor. MT-228 markedly improves tolerability by selectively targeting NMIIB (KI = 1.5 μM) over CMII (KI = 17 μM), and the sequence of SmMll MD is 83.6% identical to that of NMllB. MT-228 shows long-lasting efficacy in animal models of stimulant use disorder.

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MT-228 Chemical Structure

MT-228 Chemical Structure

CAS No. : 2404652-24-8

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MT-228 Related Antibodies

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Description

MT-228 is a selective and blood-brain barrier permeable non-muscle myosin II inhibitor. MT-228 markedly improves tolerability by selectively targeting NMIIB (KI = 1.5 μM) over CMII (KI = 17 μM), and the sequence of SmMll MD is 83.6% identical to that of NMllB. MT-228 shows long-lasting efficacy in animal models of stimulant use disorder[1].

In Vitro

MT-228 (10-3-100 μM) shows improved cardiac safety and selectivity compared to Blebbistatin (HY-13813) with a KINMIIB of 1.5 μM in an ATPase assay[1]. MT-228 shows excellent agreement with the cytokinesis (EC50 = 1.0 μM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

MT-228 Related Antibodies
In Vivo

MT 228 (5-10 mg/kg, i.p., single dose) is well-tolerated up to at least 10 mg/kg in mice[1].
MT-228 (0.5-5 mg/kg, i.p. or i.v., single dose) disrupts the motivation for stimulant in mice and rats[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: 8-10-week-old male C57BL/6 mice (25-30 g)[1]
Dosage: i.p. for a single dose
Administration: 5, 7.5, 10 mg/kg
Result: Showed no significant effects on distance travelled over the first 10 minutes or entire 40 minutes test period post-injection.
Showed no effect on velocity and no difference between time spent in the center versus the sides of the open field.
Animal Model: 8-10-week-old male C57BL/6 mice (25-30 g)[1]
Dosage: i.p. for a single dose
Administration: 0.5, 1, 2.5, 5 mg/kg
Result: Disrupted the motivation for METH at doses as low as 0.5 mg/kg.
Had no effect on a strong preference for the COC-paired chamber (5 mg/kg).
Had no effect on any measure in elevated plus maze, including the total distance travelled in the maze, latency to enter the open (unprotected) arm, or time spent in the open arm(5 mg/kg).
Animal Model: Adult male 250-300 g rats[1]
Dosage: i.v. for a single dose 30 minutes before testing
Administration: 1 mg/kg
Result: Reduced the robust lever pressing displayed by rats.
Removed the motivation to seek METH for at least one month.
Molecular Weight

337.37

Formula

C19H19N3O3
CAS No.
SMILES

O=C1[C@@]2(O)C(N(C3=CC(OC)=NC=C3)CC2)=NC4=C1C=C(C)C(C)=C4
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Purity & Documentation
References
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MT-228 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

MT-2282404652-24-8BPN-0026709MT228MT 228BPN0026709BPN 0026709Myosinnon-muscle myosin IIstimulant use disorderInhibitorinhibitorinhibit

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