2. Protein Tyrosine Kinase/RTK
  3. FLT3
  4. FLT3-IN-32 TFA

FLT3-IN-32 TFA is a potent FLT3 inhibitor with an IC50s of 2.40 nM and 3.83 nM against FLT3-ITD and FLT3-D835Y. FLT3-IN-32 TFA inhibits proliferation/survival of human MV4-11 cells with an IC50 of 0.07 nM. FLT3-IN-32 TFA can be used for the study of acute myeloid leukemia (AML).

For research use only. We do not sell to patients.

FLT3-IN-32 TFA

FLT3-IN-32 TFA Chemical Structure

CAS No. : 3047195-49-0

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Other Forms of FLT3-IN-32 TFA:

FLT3-IN-32 TFA Related Antibodies

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Description

FLT3-IN-32 TFA is a potent FLT3 inhibitor with an IC50s of 2.40 nM and 3.83 nM against FLT3-ITD and FLT3-D835Y. FLT3-IN-32 TFA inhibits proliferation/survival of human MV4-11 cells with an IC50 of 0.07 nM. FLT3-IN-32 TFA can be used for the study of acute myeloid leukemia (AML)[1].

In Vitro

FLT3-IN-32 TFA (Compound 29b) exhibits antiproliferative activity against EOL-1 (IC50 = 0.02 nM), MOLM-13 (IC50 = 0.20 nM), MONO-MAC-1 (IC50 = 100 nM) and MONO-MAC-6 (IC50 = 0.65 nM)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

FLT3-IN-32 TFA Related Antibodies
Molecular Weight

629.58

Formula

C30H30F3N5O7
CAS No.
SMILES

O=C(NC1=CC2=C(OC(C(C3=CC4=C(CN(C)C)C(O)=CC=C4N3)=O)=C2)C=C1)NC5=NOC(C(C)(C)C)=C5.O=C(O)C(F)(F)F
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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FLT3-IN-32 TFA Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

FLT3-IN-323047195-49-0FLT3Cluster of differentiation antigen 135CD135Fms like tyrosine kinase 3Acute myleoid leukemiaFLT3 mutationsIn vivo mouse modelType I/II inhibitorTyrosine kinase inhibitorInhibitorinhibitorinhibit

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