2. Vitamin D Related/Nuclear Receptor
  3. Estrogen Receptor/ERR
  4. ZN-c5

ZN-c5 is a selective and orally active estrogen receptor degrader. ZN-c5 exhibits high potency in the cellular assay (MCF-7 IC50 = 0.3 nM) and binds with high affinity to ERα and ERβ (IC50 = 0.4 nM and 0.8 nM, respectively). ZN-c5 inhibits tumor growth in MCF-7 mouse xenograft model and WHIM20 xenograft model. ZN-c5 can be used for the study of breast cancer.

For research use only. We do not sell to patients.

ZN-c5 Chemical Structure

ZN-c5 Chemical Structure

CAS No. : 2136606-87-4

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ZN-c5 Related Antibodies

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Estrogen receptor ERα ERβ ERRα ERRβ ERRγ

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Description

ZN-c5 is a selective and orally active estrogen receptor degrader. ZN-c5 exhibits high potency in the cellular assay (MCF-7 IC50 = 0.3 nM) and binds with high affinity to ERα and ERβ (IC50 = 0.4 nM and 0.8 nM, respectively). ZN-c5 inhibits tumor growth in MCF-7 mouse xenograft model and WHIM20 xenograft model. ZN-c5 can be used for the study of breast cancer[1].

In Vitro

ZN-c5 (100 nM, 24 h) induces ERα degradation in breast cancer cell lines (MCF-7, ZR-75-1, CAMA-1, HCC1500 and HCC1428 cells)[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

ZN-c5 Related Antibodies

Western Blot Analysis[1]

Cell Line: MCF-7, ZR-75-1, CAMA-1, HCC1500 and HCC1428 cells
Concentration: 100 nM
Incubation Time: 24 h
Result: Induced ERα degradation in breast cancer cell lines.
In Vivo

ZN-c5 (1-40 mg/kg, p.o., once daily, 28 days) shows significant tumor growth inhibition in MCF-7 mouse xenograft model[1].
ZN-c5 (40 mg/kg, p.o., once daily, 90 days) induces tumor growth inhibition in the WHIM20 xenograft model (an ESR1 mutant model (Y537S))[1].

MedChemExpress (MCE) has not independently confirmed the accuracy of these methods. They are for reference only.

Animal Model: BALB/c nude mice were inoculated subcutaneously on the second right mammary fat pad with the single cell suspension of 95% viable tumor cells (1.5 × 107) in 200 μL medium Matrigel mixture (1:1 ratio) without serum[1]
Dosage: 1, 5, 40 mg/kg
Administration: p.o. once daily for 28 days
Result: Resulted in complete tumor growth inhibition at 5 mg/kg.
Animal Model: Female athymic BALB/c nude mice were implanted with a single cell suspension of 1.5 × 106 WHIM20 cells[1]
Dosage: 40 mg/kg
Administration: p.o. once daily for 90 days
Result: Induced tumor growth inhibition and showed no loss in body weight.
Molecular Weight

434.48

Formula

C26H24F2N2O2
CAS No.
SMILES

FC1=CC(/C=C/C(O)=O)=CC(F)=C1[C@H]2N([C@@H](CC3=C2NC4=CC=CC=C43)C)C56CC(C6)C5
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Room temperature in continental US; may vary elsewhere.
Storage

Please store the product under the recommended conditions in the Certificate of Analysis.
Purity & Documentation
References
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ZN-c5 Related Classifications

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Help & FAQs
  • Do most proteins show cross-species activity?

    Species cross-reactivity must be investigated individually for each product. Many human cytokines will produce a nice response in mouse cell lines, and many mouse proteins will show activity on human cells. Other proteins may have a lower specific activity when used in the opposite species.

Keywords:

ZN-c52136606-87-4Estrogen Receptor/ERRMCF-7WHIM20estrogen receptorbreast cancerInhibitorinhibitorinhibit

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